Small rodents serve as reservoir hosts for tick-borne pathogens, such as the spirochetes causing Lyme disease. Whether natural coinfections with other macroparasites alter the success of tick feeding, antitick immunity, and the host's reservoir competence for tick-borne pathogens remains to be determined. In a parasitological survey of wild mice in Berlin, Germany, approximately 40% of Ixodes r...

Tick-borne borreliosis in West Africa is classically considered a rare disease whose geographic distribution is limited to Saharan and Sahelian regions. We report results of epidemiological investigations which indicate that tick-borne borreliosis is endemic in all regions of Senegal north to the 13 degrees 30'N latitude and is a major cause of morbidity in these areas. Our findings indicate a ...

This proposal represents the cooperative efforts of the international tick research community to develop the first large scale genomic analysis of a medically significant tick, namely Ixodes scapularis. Ticks transmit the greatest variety of human and animal pathogens of any arthropod vector and are second only to mosquitoes as vectors of human disease (Fivaz et al., 1992; Sonenshine and Mather...

Several important human diseases worldwide are caused by tick-borne viruses. These diseases have become important public health concerns in recent years. The tick-borne viruses that cause diseases in humans mainly belong to 3 families: Bunyaviridae, Flaviviridae, and Reoviridae. In this review, we focus on therapeutic approaches for several of the more important tick-borne viruses from these 3 ...

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks...

Ticks transmit more pathogens-including bacteria, parasites and viruses-than any other arthropod vector. Although the epidemiological status of many tick-borne bacteria is very well characterized, tick-borne viruses are still relatively under-studied. Recently, several novel tick-borne viruses have been isolated from human febrile illnesses following tick bites, indicating the existence of othe...

In July 2016, the first autochthonous case of tick-borne encephalitis was diagnosed in the Netherlands, five days after a report that tick-borne encephalitis virus (TBEV) had been found in Dutch ticks. A person in their 60s without recent travel history suffered from neurological symptoms after a tick bite. TBEV serology was positive and the tick was positive in TBEV qRT-PCR. TBEV infection sho...

Ticks are obligate haematophagous arthropods present all over the world able to produce human diseases. Several factors have increased the abundance, circulation and distribution of the pathogens transmitted by ticks, contributing to the change in the vector-borne diseases epidemiology in the last years. This review collects the most important measures for the prevention and prophylaxis of tick...

Climate change is affecting human health worldwide. In particular, changes to local and global climate parameters influence vector water-borne diseases like malaria, dengue fever, tick-borne encephalitis. The Republic of Sakha in northern Russia no exception. Long-term trends increasing annual temperatures thawing permafrost have corresponded with the northward range expansion tick-species Repu...

BACKGROUND Our aim was to identify the mechanisms of immune and cytokine regulation in different clinical forms of Ixodes tick-borne borreliosis. METHODS The clinical observations performed on 581 patients with erythemic (113 patients), non-eritemic (242 patients) forms of Ixodes tick- borne borreliosis and Borrelia co-infection tick-borne encephalitis (226 patients) in the manifestation of t...