BACKGROUND Thyroid antibody testing is not routinely available in developing countries, and few studies have measured thyroid antibodies in Africans. The significance of thyroid autoimmunity in an African setting is thus unclear. AIM To determine the prevalence of thyroid antibodies in patients attending a Nigerian teaching hospital. DESIGN Prospective survey. METHODS We measured antibodi...

INTRODUCTION Anti-thyroid antibodies are associated with extra-thyroid diseases such as Graves' ophthalmopathy and Hashimoto's encephalopathy. Some evidence suggests that anti-thyroid antibodies are also associated with depression. Interleukin (IL)-17 appears to play an important role in autoimmune thyroid disease. This study investigated whether specific thyroid autoantibodies and IL-17 distin...

Abbreviations: Ab, antibody; ALP, alkaline phospha atrazine conjugated with horseradish peroxidase; CE, c nanotubes; CV, cyclic voltammetry; ELISA, enzyme-linke high-density polyethylene; HRP, horseradish peroxid magnetic beads; NP, nanoparticle; PAP, p-aminoph phosphate; PET, polyethylene terephthalate; POC, point electrode; RT, room temperature; TMB, 3,3′,5,5′-tetramet tetramethylbenzidine di...

BACKGROUND Thyroid hormone plays a critical role in fetal development. In pregnancy, increased thyroid hormone synthesis is required to meet fetal needs, resulting in increased iodine requirements. OBJECTIVE This article outlines changes to thyroid physiology and iodine requirements in pregnancy, pregnancy specific reference ranges for thyroid function tests and detection and management of th...

Background: Thyroid autoimmunity and thyroid dysfunction is predominant in women of procreative age has been linked with hostile fertility. Objective: To evaluate the association unexplained infertility (UI). Material Methods: A case-control study was performed by department Physiology Basic Medical Sciences Institute collaboration Jinnah Postgraduate Centre, Karachi from May 2018 to June 2019....

BACKGROUND Thyrotropin-producing pituitary tumor is relatively rare. In particular, concurrent cases associated with Graves' disease are extremely rare and only nine cases have been reported so far. We describe a case of a thyrotropin-producing pituitary adenoma concomitant with Graves' disease, which was successfully treated. CASE PRESENTATION A 40-year-old Japanese woman presented with mild...

Objectives: To establish the prevalence and incidence of thyroid dysfunction during pregnancy in a tertiary care center Bangladesh. Methodology: 749 cases were randomly selected among pregnant women who reported to antenatal clinic. Later 121 excluded as they already diagnosed disorder. The rest investigated for stimulating hormone (TSH) if required then also free triiodothyronine (FT3), thyrox...

Background: Premature ovarian failure (POF) is a disorder of multi causal etiology. Autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in POF. The aim of this study was to identify the level of auto-antibodies in POF and familial POF patients. Materials and Methods: In this study, auto-antibodies including anti-ovarian antibody (AOA), a...