BACKGROUND Sorafenib is a multi-targeted tyrosine kinase inhibitor licensed for the treatment of hepatocellular carcinoma and renal cell carcinoma. Thyroid function test abnormalities have been reported for different tyrosine kinase inhibitors, but only limited data on thyroid function test abnormalities related to sorafenib are available, demonstrating the occurrence of hypothyroidism in patie...

background: fanconi anemia (fa) is a rare, autosomal recessive (ar) and multifactorial disorder. a high prevalence of fa observed in iran is perhaps due to the high rate of consanguineous marriages. this study investigates the extent of short stature in patients with fa, the frequency of hypothyroidism in fa and the correlation between height and hypothyroidism.   methods: eighteen patients wit...

Background: Thyroid function disorders, particularly congenital hypothyroidism (CHT), are important endocrine dysfunctions associated with permanent morbidities. CHT is more prevalent among preterm low-birth-weight neonates compared to term infants with normal weight. Methods: This prospective cohort study was conducted on 126 very-low-birth-weight (VLBW) neonates referred to the neonatal inten...

Fasting is one of Islamic Five Pillars and it is an Islamic obligations. Even though fasting during Ramadan month is an obligatory, if this obligatory has dangerous effects on the human health, it is forbidden. In On the other hand, atypical levels of thyroid hormones can create serious problems for human body and normal range of these hormones is indicative of good thyroid function. The presen...

Hypothyroidism is a recognized side effect of thalidomide drugs. We herein report a case of 83-year-old Irish female with a diagnosis of multiple myeloma and a background history of type 2 diabetes mellitus and hypertension. Our patient received pomalidomide and multiple courses of chemotherapy and achieved very good initial response for her multiple myeloma but subsequently she relapsed. She d...

The usefulness of the various tests of thyroid function has been evaluated over a three-year period. It is concluded that an uptake test and estimation of the serum protein-bound radioactive iodine (PB (131)I), supplemented as required by the protein-bound iodine (PBI), remain the best routine tests of thyroid function. Forty-five patients who gave discordant results on these tests over this pe...

Background: Transient neonatal hyperthyrotropinemia (TNH) occurs frequently in areas of iodine deficiency and may affect intellectual function and psychomotor performance. Design: A historical cohort study of intellectual development, psychomotor performance, urine iodine and thyroid function tests, performed in 9 years children with documented TNH at birth and control group. Subjects: Eighte...

OBJECTIVE: Due to the increased prevalence of thyroid dysfunction in subjects with type 2 diabetes and also this fact that antibodies could potentially identify subjects at risk of thyroid dysfunction, this study was conducted to investigate thyroid autoimmunity in type 2 diabetic patients. MATERIAL AND METHODS: Among patients referred to Yazd Diabetes Research Center, 4000 type 2 diabetic pat...

objective: due to the increased prevalence of thyroid dysfunction in subjects with type 2 diabetes and also this fact that antibodies could potentially identify subjects at risk of thyroid dysfunction, this study was conducted to investigate thyroid autoimmunity in type 2 diabetic patients. material and methods: among patients referred to yazd diabetes research center, 4000 type 2 diabetic pati...