Since use of antinoceceptive chemical drugs for relief of pain has many side effects, medical plants seem very noticeable today. Previous findings indicate that Carum Carvi (CC) modulates pain in both animal and human. The present work investigated the effects of hydoalcoholic extract of CC on acute pain in Hot plate and Tail flick models. Albino mice (20-30 g) were used for this study. Hydroal...

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

Nicotinic agonists display a wide-range profile of antinociceptive activity in acute, tonic, and chronic pain models. However, their effectiveness is limited by their unacceptable side effects. We investigated the antinociceptive effects of two new α4β2* nicotinic partial agonists, varenicline and sazetidine-A, in acute thermal and tonic pain mouse models. Both drugs failed to induce significan...

the seeds of peganum harmala l. ( pgh ) (zygophyllaceae) have been used in moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process. the major objective of this paper was to investigate the analgesic effect of ethyl acetate (eae), butanolic (be) and aqueous (aqe) extracts of seeds of peganum harmala and elucided the possible underlying action mechanism o...

The analgesic effect and possible mechanism(s) of action of 50-200 mg/kg of the aqueous seed extract of H. umbellata (HU) were investigated in different experimental models of analgesia using the tail flick, tail immersion, acetic acid-induced writhing tests and formalin-induced algesia. Oral pre-treatment with 50-200 mg/kg of HU caused significant and dose related analgesic effect in the treat...

Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effect of cannabinoid receptor agonist, WIN55,212-2, microinjected into the BLA fo...

Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report the comorbidity of pain and depression-like behavior. The antidepressant and analgesic like activity of Ondansetron (OND, 0.25-2mg/kg) were investigated in animal models of acute depression (forced swim test ) and pain ( tail flick test) , existe...

Results: TT treatment of diabetic rats reduced pain score only in chronic phase of the formalin test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05). Although TT treatment of diabetic rats i...

Since use of antinoceceptive chemical drugs for relief of pain has many side effects, medical plants seem very noticeable today. Previous findings indicate that Carum Carvi (CC) modulates pain in both animal and human. The present work investigated the effects of hydoalcoholic extract of CC on acute pain in Hot plate and Tail flick models. Albino mice (20-30 g) were used for this study. Hydroal...