Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunolo...

LTHOUGH the thymus has been proved to play an essential role in the development and maintenance of immune reactivity, the mechanisms by which it exerts these functions are still to be elucidated. While significant titers of antibody”2 or plasma cell accumulation3’4 have not been detected in the intact thymus of animals given antigens at distant site, histologic signs indicative of local antibod...

This study aims to determine the effect of providing a combination commercial fermented feed on resistance super native chicken. The was conducted from October December 2019 in Popalia village Tanggetada Kolaka district. material used is 60 chicken DOC. arranged completely randomized design 4 treatments and 3 replication P1 (40% + 60% feed), P2 (50% 50% P3 (60% 40% P4 (70% ferment 30% feed). pa...

We developed a novel experimental strategy to study T cell regeneration after bone marrow transplantation. We assessed the fraction of competent precursors required to repopulate the thymus and quantified the relationship between the size of the different T cell compartments during T cell maturation in the thymus. The contribution of the thymus to the establishment and maintenance of the periph...

The role of the thymus in propylnitrosourea (PNU)-induced thymic lymphomagenesis was studied in F344 rats with genetically determined high susceptibility. The thymus was absolutely required for thymic lymphomagenesis, since thymectomy prior to or after PNU treatment abolished lymphomagenesis, whereas grafting of a normal neonatal thymus before PNU treatment restored it. Exposure to PNU for 42 d...

The development pathway from embryonic thymus-stem cell to peripheral thymus-derived lymphocyte has been demonstrated using the alloantigens theta (theta) and TL as surface markers of cell differentiation. On the basis of cytotoxicity tests carried out on CBA.H or A embryo thymus cultured in diffusion chambers and on CBA.H embryo thymus grafts and peripheral lymphocytes derived from them in AKR...

The thymus and parathyroid glands arise from a shared endodermal primordium in the third pharyngeal pouch (3rd pp). Thymus fate is specified in the ventral 3rd pp between E9.5 and E11, whereas parathyroid fate is specified in the dorsal domain. The molecular mechanisms that specify fate and regulate thymus and parathyroid development are not fully delineated. Previous reports suggested that Tbx...

The reduced immunological responsiveness of neonatally thymectomized rodents has been reversed far more effectively with cells from spleen, lymph nodes, and thoracic-duct lymph than with cells from either thymus or bone marrow.' In heavily irradiated mice, an inoculum containing a mixture of marrow and thymus cells allowed the production of more hemolysins against sheep erythrocytes than could ...