A 25-year old male presented with a 3 year history of recurrent spontaneously remitting swelling of any of his limbs and appearance of painful cord-like structures over different areas of the swollen limbs which would also resolve spontaneously. The patient also complained of pain in his lower limbs upon walking which had increased in severity over past one year. Clinical examination revealed a...

230-240, 1977 24. Sundt TM Jr, Waltz AG: Cerebral ischemia and reactive hyperemia. Studies of cortical blood flow and micTocirculation before, during, and after temporary occlusion of middle cerebral artery of squirrel monkeys. Circ Res 28: 426-433, 1971 25. Rosenthal M, La Manna JC: Effect of ouabain and phenobarbital on the kinetics of cortical metabolic transients associated with evoked pote...

Thromboangiitis obliterans (TAO) is an unusual tobacco-associated vasculopathy that is a nonatherosclerotic inflammatory disorder of unknown etiology that affects small and mediumsized vessels of the extremities. The single guanosine nucleotide deletion/insertion polymorphism (4G/5G) at -675 bp in promoter region of the PAI-1 gene is the major genetic determinant of PAI-1 expression. Plasma PAI...