To understand the dynamics of the cell cycle, we need to characterize the balance between cell cycle arrest and cell proliferation, which is often deregulated in cancers. We address this issue by means of a detailed computational model for the network of cyclin-dependent kinases (Cdks) driving the mammalian cell cycle. Previous analysis of the model focused on how this balance is controlled by ...

Interest in extending the high cycle fatigue life of structures has increased in the last decade of the 20th century. Since a long fatigue life depends on keeping cyclic loads near or below the fatigue threshold, understanding near-threshold behavior is now all the more important. This paper reviews the status of the ‘threshold of fatigue’ and to a lesser extent its relation to the ‘fatigue lim...

We consider a three-term nonlinear recurrence relation involving a nonlinear filtering function with a positive threshold λ. We work out a complete asymptotic analysis for all solutions of this equation when the threshold varies from 0 to ∞. It is found that all solutions either tends to 0, a limit 1-cycle, or a limit 2-cycle, depending on whether the parameter λ is smaller than, equal to, or g...

Threshold tracking was used to compare excitability properties (stimulus-response curves, strength-duration properties, recovery cycle and threshold electrotonus) of the median nerve in 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 25 healthy controls. Stimulus-response curves were significantly different: threshold was much higher, the slope of the curves reduce...

Regulation of cyclin abundance is central to eukaryotic cell cycle control. Strong overexpression of mitotic cyclins is known to lock the system in mitosis, but the quantitative behavior of the control system as this threshold is approached has only been characterized in the in vitro Xenopus extract system. Here, we quantitate the threshold for mitotic block in budding yeast caused by constitut...

We present a new method which enables us to find threshold functions for many properties in random intersection graphs. This method is used to establish sharp threshold functions in random intersection graphs for k–connectivity, perfect matching containment and Hamilton cycle containment.

Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic inducers, and thus the ability to resume cell division. This permanent cell cycle exit depends on p21, p53, and APC/C(Cdh1). However, when and how pe...

We hypothesized that a 10-s rest interval (at zero load) inserted between each load cycle would increase the osteogenic effects of mechanical loading near previously identified thresholds for strain magnitude and cycle numbers. We tested our hypothesis by subjecting the right tibiae of female C57BL/6J mice (16 wk, n = 70) to exogenous mechanical loading within a peri-threshold physiological ran...

This paper presents a new concept of continuous-valued logic (Multi level logic) (CVL) which can be applied to control the pulse width of an internally generated PWM in a microcontroller. The input threshold voltage controls duty cycle of generated PWM. The basis of continuous-valued logic (CVL) relies on the unstable generated oscillation of a digital output where the program referred non-Schm...

Hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptionally activates multiple genes, which regulate metabolic cardioprotective and cross-adaptive mechanisms. Hypoxia and several other stimuli induce the HIF-1alpha signaling cascade, although little data exist regarding the stress threshold for activation in heart. We tested the hypothesis that relatively mild short-cycle hypoxia, which prod...