In ER+ eBC, extending AIs beyond 5 years reduces late recurrences at the price of increased skeletal events. Germline SNPs CYP19A1 may affect aromatase activity, potentially leading to decreased efficacy and toxicity. We conducted a prospective study assess impact on outcomes 886 postmenopausal patients treated with AIs. The included 2 cohorts who were free relapse 3-6 from diagnosis. Patients ...

BACKGROUND Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool suitable for BC detection and staging in which the glucose analog supplies metabolic information about the tumor. A limited number of studies, sometimes controversial, describe...

Black carbon (BC), an important component of organic carbon (OC) produced from incomplete combustion of carbon compounds, is widespread and affects the global carbon storage. The objectives of this study were to analyze the BC contents and fluxes in the last 150 years to determine the causes of differences in the three profiles of the Songnen Plain of Northeast China and to estimate the BC stor...

The strain Streptomyces coelicoflavus BC 01 was isolated from mangrove soil and used as inoculum for submerged fermentation. The fermented broth was extracted with ethyl acetate, the crude extract was subjected to silica gel column chromatography and the homogeneity of the isolated fractions was determined by TLC and then subjected to RP-HPLC for their purity. The purification steps led to the ...

background: the occurrence and the mortality related to breast cancer (bc) in iranian female population has increased over time. although there are many studies on bc and related risk factors, however, the epidemiological aspects of this melanoma in iranian females are uncertain. therefore, the aim of this study was to determine the relationship between demographical and clinical factors on the...

Serum lysozyme gene is one of the important genes influencing the immune system as its product can cause lysis of bacterial cell wall by cleaving the peptidoglycan layer. The present investigation on the serum lysozyme gene of Indian riverine buffalo was undertaken with the objectives to identify and characterize single nucleotide polymorphic patterns by PCR-SSCP method as well as to study the ...

Introduction: The growing trend of cancer incidence in the past few decades and its effects on physical, psychological, spiritual, and social dimensions both in patients and their families make cancer one of the major health hazards of the century. Of all cancers, breast cancer (BC) is the most prevalent among females. Thus, the current study aimed at comparing three components of BC between fe...

This investigation assessed effects of three increasingly inclusive versions of the Behavioral Consultation (BC) model on problem behavior of students in mainstream classrooms in an effort to develop an effective and efficient approach to prereferral intervention. Subjects were 43 general educators, their 43 most difficult-to-teach students (without disabilities), and 12 school consultants, rep...