Phytoconstituents have been used in medicine science since ancient times due to their various pharmacological actions. But most of them (like flavanoids, terpenoids) are low in lipid solubility and have large molecular size due to complex multiple ring structure, causing poor absorption and poor bioavailability via oral route. The phytosome system of drug delivery results in increased bioavaila...

Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with milk thistle or black cohosh modified P-gp activity in vivo. Sixteen healthy volunteers were randomly assigned to receive a standardized milk t...

Extracts of milk thistle have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. Milk thistle extracts are now under intense study in the experimental therapeutics of cancer for chemoprevention, treatment, and amelioration of chemotherapy side effects. Precision in nomenclature, howe...

The plant, Centaurea perrottetii DC (Asteraceae) is a herbaceous thistle-like shrub used in traditional medicine for the treatment of malaria, fever, syphilis, ulcer and skin infections. aim study to isolate elucidate structure compound(s) from C. perrottetii. Quercetin-derivative (an amino-flavone) was isolated n-hexane fraction methanol extract whole plant using combination silica gel column ...

Cnicus wallichi DC belonging to the family Asteraceae (Compositae) commonly known as Indian thistle and cirsium wallichi. It is an important medicinal plant indigenous to Nilgiris, Tamilnadu, South India. Since the related species Cnicus benedictus was reported for its anti cancer activities, In vitro screening studies for antitumour activities were carried out for different extracts of Cnicus ...

UNLABELLED Milk thistle extracts have been used as medicinal herbs in the treatment of liver cirrhosis, chronic hepatitis (liver inflammation), and gallbladder disorders. Treatment claims also include lowering cholesterol levels; reducing insulin resistance; reducing the growth of cancer cells in breast, cervical, and prostate gland cancers; and antiviral activity. Other reported uses of milk t...

introduction:the prevalence of atopic diseases has increased in recent decades dramatically. the most common aeroallergens in northeastern iran have not been fully defined. define the most common aeroallergens in allergic patients based on the skin prick test (spt) was aimed in this investigation.materials and methods:this cross-sectional study enrolled 1,006 allergic patients (aged 1–86 years)...

Understanding the role of consumers in density-dependent plant population dynamics is a long-standing goal in ecology. However, the generality of herbivory effects across heterogeneous landscapes is poorly understood due to the pervasive influence of context-dependence. We tested effects of native insect herbivory on the population dynamics of an exotic thistle, Cirsium vulgare, in a field expe...