This paper is concerned with the analysis of zero-inflated count data when time of exposure varies. It proposes a modified zero-inflated count data model where the probability of an extra zero is derived from an underlying duration model with Weibull hazard rate. The new model is compared to the standard Poisson model with logit zero inflation in an application to the effect of treatment with t...

The title compound, C(12)H(17)N(3)S, was prepared by the reaction of 4-ethyl-thio-semicarbazide and 3,4-dimethyl-benzaldehyde. The dihedral angle between the thiourea unit and the benzene ring is 7.09 (8)°. In the crystal, inversion dimers linked by pairs of N-H⋯S hydrogen bonds occur.

Treatment with three daily doses (3-10 gg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments. In tumors from mice having other treatment schedules and in livers from all groups no definite change ...

The worldwide incidence of multiple myeloma (MM) has been rising continuously, representing an overall increase 126% from 1990 to 2016 in almost all regions, regardless socio-demographic status and availability sensitive diagnostic techniques.1 Though remarkable progress made, the disease is still currently incurable. Nearly 13% patients will develop extramedullary due natural accumulation muta...

AIM OF THE STUDY Resistance to imatinib is one of the most important issues in treatment of chronic myeloid leukemia (CML) patients. The objective of the study was to analyze the ex vivo drug resistance profile to bortezomib and 22 other antileukemic drugs, including three tyrosine kinase inhibitors (TKIs), in CML in comparison to acute myeloid leukemia (AML). MATERIAL AND METHODS A total of ...

The suppression of tumor tissue (as measured by tumor weight) and the destruction of bone marrow (as measured by the number of nucleated cells per mouse femur) were determined at several dose levels of each of the compounds investigated. The least reduction in the quantity of marrow cells occurred in the animals treated with 3',5'-dichloroaminopterin and mitomycin C. In contrast, marked suppres...