The recent introduction of diaminodiphenylsulfone (DDS) and the thiosemicarbazones represents a significant contribution in the treatment of leprosy. The efficacy of DDS has been confirmed by a number of well-controlled observations (1, 2, 4, 5, 8, 10, 11). The effectiveness of thiosemicarbazone still remains to be evaluated (3, 7, 9, 12, 13, 14). For both drugs, the periods of observation have...

Discovered by Waksman et al. (1944), streptomycin was first tried extensively by Feldman and Hinshaw (1945). Synthesized in the year 1889, para-amino-salicylic acid has been studied in detail both in the United States of America and Western Europe (Lehmann, 1946). Similarly, thiosemicarbazone was developed by Professor Domagk (1946) and para-acetyl-aminobenzaldehyde thiosemicarbazone was studie...

A series of 111 thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds were evaluated as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model. All derivatives tested were potent inhibitors of virus replication with mean 50% inhibitory concentrations of 1.1 micrograms/ml for both type 1 and 2 herpes simplex virus. ...

Stoichiometry and stability of Ga(III), Fe(III), Fe(II) complexes of Triapine and five related α-N heterocyclic thiosemicarbazones with potential antitumor activity have been determined by pH-potentiometry, UV-vis spectrophotometry, (1)H NMR spectroscopy, and spectrofluorimetry in aqueous solution (with 30% DMSO), together with the characterization of the proton dissociation processes. Addition...

Some 2-iminothiazolidin-4-ones have been synthesized by the reaction of dialkyl acetylenedicarboxylates with thiosemicarbazones. The reaction was performed in the presence of 10 mol% of triphenylphosphine and tetrabutylammonium bromide as a phase transfer catalyst in water as a green solvent. All the synthesized compounds were characterized by their physical and spectral data.

A series of novel bis-thiazolidinone derivatives 3(a-j) have been synthesized by the cyclization thiosemicarbazones 2(a-j) with chloroacetic acid and sodium acetate. The integrated heterocyclic compounds were featured chemical spectroscopic methods such as IR, 1H NMR 13C NMR. All screened for their antimicrobial activity against Gram-positive Gram-negative bacteria Staphylococcus Aureus, Bacill...

For the discovery of new antimicrobial drugs, derivatives sulfonamide having thiazole ring were synthesized. The series synthesized starting from 4-(arylsulfonamido)-acetophenone thiosemicarbazones 2a–f. Cyclization thiosemicarbazone 2a–f by using ethyl chloroacetate and chloroacetone gave thiazolidin-4-ones 3a–f 4-methylthiazoles 4a–e, respectively. properties compounds investigated. major no ...

The influence of substituents at the C(2) carbon of N(1)-substituted thiosemicarbazones, {C(4)H(3)X-C(2)(CH(3))=N(3)-N(2)H-C(1)(=S)N(1)HR(2)} (X = O, S) on the geometry of nickel(ii) complexes has been investigated. The presence of a methyl group at the C(2) position of 2-acetylfuran-N(1)-substituted thiosemicarbazones {(C(4)H(3)O)-C(2)(CH(3))=N(3)-N(2)H-C(1)(=S)N(1)HR(2), R(2) = CH(3), HaftscN...