We report an interesting phenomenon we recently encountered in our hospital. Our patient was a healthy man who came in for an emergency hernia repair due to suspected obstruction. Previous anaesthesia for an orthopaedic operation the previous year had been uneventful. The plan was to anaesthetize him with a rapid sequence induction. This was done in view of the increased risk of aspiration give...

A number of papers have been presented in support of the concept that epinephrine potentiates barbiturate anesthesia in experimental animals (1-3). Recently, Mazel et al. (4) reported that epinephrine increased the brain level of barbital above controls and suggested that epinephrine may affect the permeability of the blood-brain barrier as well as other barriers. However, mechanism of the pote...

4. Hallett, E.: A study of intraocular tension during general anesthesia, Tr. Ophth. Soc. XXIV: 73, 1965. 5. Sampaolesi, R., Reca, R., and Carro, A.: Personal communication, Oct., 1967. 6. de Roetth, A., Jr. and Schwartz, H.: Aqueous humor dynamics in glaucoma: Effect of ganglionic blocking agents and thiopental sodium anesthesia on aqueous humor dynamics, Arch. Ophth. 55: 755, 1956. 7. Apt, L....

Objective- To compare the effects of xylazine-ketamine and xylazine-thiopental on cardiac rhythm indogs.Design- Experimental study.Animals- 15 mixed-bred, adult dogs of either sex.Procedures- Following premedication with xylazine HCI, either ketarnine HCI or sodium thiopentalwere administered to dogs. Cardiac rhythm was evaluated before as well as 15,30,45, and 60 minutes and3 days after induct...

ISSN © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. Dear Editor, Sugammadex is a modifi ed gamma cyclodextrin . Cyclodextrins are water soluble cyclic oligosaccharides with a lipophilic core. Sugammadex has quickly found a place in clinical use for selective antagonism of neuromuscular blockade with rocuronium . Sugammadex quickly encapsulates steroidal neuro...

BACKGROUND Previous evidence from laboratory animal studies indicates that R-thiopental has a greater margin of safety than either the more potent S-thiopental or the clinically used rac-thiopental. Although thiopental can cause cardiovascular depression from direct myocardial effects as well as indirect central nervous system and peripheral effects, no studies have yet determined whether its m...