one series of half-analogues of michler’s ketone containing one or more terminal methoxysubstituents with variable tertiary amino groups have been used in this study. nmr spectralresults for the parent ketones confirm earlier findings that ortho proton shifts are apparentlyindependent from steric effects in derivatives of michler’s ketone because the ring current andcarbonyl-induced shifts are ...

Rates of plasma acetoacetate and total ketone-body production and oxidation to CO2 were determined by an isotope tracer technique in eight obese subjects undergoing progressive starvation. After a brief fast and under conditions of mild ketonemia and minimal ketonuria, rates of acetoacetate and total ketone-body production and oxidation were directly related to the increasing plasma concentrati...

Ketone bodies are metabolized through evolutionarily conserved pathways that support bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when carbohydrates are in short supply. The metabolism of ketone bodies interfaces with the tricarboxylic acid cycle, β-oxidation of fatty acids, de novo lipogenesis, sterol biosynthesis, glucose metabolism, the mitochondrial electron t...

Mülkiyet hakkı, sahibine muhtelif yetkilerle birlikte bazı ödevler de yüklemektedir. Bu yönlerden mülkiyet hakkının kısıtlanması anlamına gelmektedir. Anayasanın 35. maddesinde, kamu yararı amacıyla kanunla sınırlanabileceği ve bu hakkın kullanılmasının toplum yararına aykırı olamayacağı düzenlenmiştir. nedenle çerçevesinde hem hukuku özel hukuk kaynaklı kısıtlamalara tâbi olmaktadır. Taşınmaz ...

Cancer cells express an abnormal metabolism characterized by increased glucose consumption owing to genetic mutations and mitochondrial dysfunction. Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively use ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tumor cells. As the Warburg effect is especially pr...

BACKGROUND The aim of our study was to determine the influence of routine ketone monitoring on hyperglycemic events (HE) and ketosis in youngsters with type 1 diabetes (T1D). METHODS Our single-site, controlled and randomized study was conducted on children and adolescents with T1D outside of remission phase. During two crossover periods of 6 months, patients (n = 22) experiencing HE tested k...

Uygulamada taşınmazlara yönelik olarak açılan davalarda, mahkemelerce “davalıdır şerhi” adı altında tapu siciline şerh verdirilmekte; hatta teknik anlamda tabirine rağmen, beyanlar hanesine yazıldığı görülmektedir. Türk Medeni Kanun (TMK) sistematiği ile uyumlu olmayan bu uygulama, Yargıtay kararlarına dayalı oluşmuştur. Benzer sorun “tapu iptal ve tescil davaları” terimiyle ilgili da bulunmakt...

Three groups of male Wistar rats were pair fed NIH-31 diets for 14 days to which were added 30% of calories as corn starch, palm oil, or R-3-hydroxybutyrate-R-1,3-butanediol monoester (3HB-BD ester). On the 14th day, animal brains were removed by freeze-blowing, and brain metabolites measured. Animals fed the ketone ester diet had elevated mean blood ketone bodies of 3.5 mm and lowered plasma g...