For assaying plasma cholinesterase (EC 3.1.1.8) activity and phenotyping by means of dibucaine inhibition, we have compared a commercially available kit, in which butyrylthiocholine is used as substrate, with two reference methods, one using benzoylcholine and the other propionylthiocholine. With 50 different samples of three of the most common genetic variants, we could clearly differentiate t...

Esters of thiocholine were shown to inhibit the crosslinking of fibrin clots by the transamidating enzyme, fibrinoligase (thrombin-activated fibrin-stabilizing factor or activated Factor XIII). Inhibition depended on the nature of the acylating group with the phenylpropionyl, phenylbutyryl, and trans-cinnamoyl esters being most effective of the compounds tested so far. Use of the thiolesters ma...

in recent years due to improvements of technology within automobile industry, design process of advanced driver assistance systems for collision avoidance and traffic management has been investigated in both academics and industrial levels. detection of traffic signs is an effective method to reach the mentioned aims. in this paper a new intelligent driver assistance system based on traffic sig...

high processing loads, need for complicated and frequent updating, and high false alarm are some of the challenges in designing anomaly detection and misuse detection systems. we propose a new network-based intrusion detection system (ids) that resolves such shortcomings. our scheme fuses anomaly detection and misuse detection systems, which has not been utilized so far in existing systems. in ...

Cholinesterase (ChE) is a group of enzymes that hydrolyze cholinester. There are two ChE isoenzymes in the blood, namely Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). Both required process sending nerve signals. The activity these will be decreased by exposure to toxic chemical agents, insecticides such as organophosphates or carbamates, anesthetic drug therapy for Alzheimer’s d...