A problem that has hindered the study of the biological properties of certain DNA adducts, such as those that form at the N7 atoms of purines, is their extreme chemical lability. Conditions are described for the construction of a single-stranded genome containing the chemically and thermally labile 8,9-dihydro-8- (N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) adduct, the major DNA adduct of th...

Voltage-gated sodium channels are dynamic membrane proteins essential for signaling in nervous and muscular systems. They undergo substantial conformational changes associated with the closed, open and inactivated states. However, little information is available regarding their conformational stability. In this study circular dichroism spectroscopy was used to investigate the changes in seconda...

Recent developments in (MEMS) fabrication techniques have exploited the properties of polymers. Traditional lithographic techniques have been used to create a template in a thick layer of photoresist that can be filled with a heat -0r-UV curable polymer and used to cast numerous replicas of Tesla channels in an elastomeric material-poly (dimethylsioloxane) (PDMS). The surface of this replica, a...