Objectives: The aim of this study was to investigate the response of human skeletal muscle myoblasts to therapeutic doses of X-irradiation. Methods: Myoblasts was established via skeletal muscle biopsies which irradiated in vitro by x-ray at doses 3, 5 and 7 Gy. Two effects of radiation were measured (acute effect after 24h and long term effect after 72h). Acute effect was monitored by interleu...

The paper by BAUMGARTNER et al. [1] raises very important questions pertaining to the interpretation and usefulness of randomised clinical trials, the use of surrogates of little relevance to the patient and the comparison of results using group average values. However, these problems are not adequately addressed. Whilst reference is given to the Global Initiative for Asthma guidelines to defin...

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. although these recommendations are not specific to children, the values can be extrapolated. this prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...

background: since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. this study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. methods: nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°c/min) ...

colorectal cancer is one of the most prevalent cancers in the world. it's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. to improve and standardize the treatment modalities in this field, much rese...

obesity with an increasing prevalence rate worldwide is correlated with multiple comorbidities. unfortunately, the currently available therapies such as the pharmacotherapy, bariatric surgery or gene-transfer technology are associated with a number of disadvantages including undesirable side effects, poor compliance or transient effectiveness. therefore, modifications of the lifestyle factors m...

sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. sirolimus must be used within a narrow therapeutic window. due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. t...