BACKGROUND The purpose of this study was to evaluate the antinociceptive effect of black raspberry (Rubus occidentalis) fruit extract (ROE) in a rat model of chronic muscle pain and examine the mechanisms involved. METHODS Adult male Sprague-Dawley rats were used, and chronic muscle pain was induced by two injections of acidic saline into one gastrocnemius muscle. For the first experiment, 50...

Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting 'the rule of 5' predicts that poor absorption or permeation is more likely when there are more than 5 H-bond donors, 10 H-bond acceptors, the molecular weight (MWT) is greater than 500 and the calculated Log P (CLogP) is greater than 5 (...

Aim The aim of this study was to investigate the impact of gender on the prediction of limited exercise capacity in heart failure (HF) patients assessed by 6 minute walk test (6-MWT). Methods In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and a Doppler echocardiographic study were performed in the same day. Conventional cardiac measurements were obtained and global LV dyssyn...

STUDY OBJECTIVES The purpose of this study was to determine the relative contribution of the instruction to maintain wakefulness versus posture change as major components determining sleep latency in the MWT as compared to the MSLT. DESIGN AND SETTING After adaptation, subjects spent 3 nights and the following days in the laboratory. On each day, Ss had eight sleep latency measurements includ...

BACKGROUND The aim of this study was to prospectively examine echocardiographic parameters that correlate and predict functional capacity assessed by 6 min walk test (6-MWT) in patients with heart failure (HF), irrespective of ejection fraction (EF). METHODS In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and an echo-Doppler study were performed in the same day. Global LV dys...

INTRODUCTION Adults with intellectual disabilities (ID) have significantly lower rates of physical activity and fitness than adults without ID. The 6-min walk test (6 MWT) is an inexpensive and simple way to test mobility and submaximal work capacity. PURPOSE To evaluate the test-retest reliability and validity of the 6 MWT in adults and seniors with ID and explore factors contributing to the...

We assess the application of microwave tomography (MWT) for detection axillary lymph nodes (ALNs) in breast cancer patients. numerically study effects limiting angular view MWT, as probes can only be placed on a limited arc around region. also possibility increasing amount retrievable information by acquiring data two consecutive steps, with single antenna set different positions. finally exper...

BACKGROUND Individuals with spinal cord injury (SCI) often use a wheelchair for mobility due to paralysis. Powered exoskeletal-assisted walking (EAW) provides a modality for walking overground with crutches. Little is known about the EAW velocities and level of assistance (LOA) needed for these devices. OBJECTIVE The primary aim was to evaluate EAW velocity, number of sessions, and LOA and th...

OBJECTIVE: Cardiac Rehabilitation Program (CRP) is a comprehensive program developed specifically for the patients aims to improve functional exercise capacity, quality of life, and psychosocial status. This study investigate effect CRP in retrospectively on who went through percutaneous coronary interference (PCI) with artery disease (CAD) diagnosis bypass graft (CABG) history.MATERIAL AND MET...