Thalidomide (Thd), a potent teratogen, was shown to have therapeutic potential in cancer, primarily in multiple myeloma (MM), yet its mechanism of action has not been elucidated. It was recently suggested that its teratogenicity is derived from interference in expression of genes regulated by GC-rich promoters by blocking the binding of SP1 transcription factor to its motif. We explored the val...

The prevalence of obesity is increasing among all Americans, including Native Hawaiians. Because obesity is a risk factor for major chronic diseases and shortens lifespan, it is important to develop and test interventions to prevent and reduce it. Traditional Hawaiian Diet (THD) programs, conducted over the last two decades, were examined in the context of national information on weight loss an...

OBJECTIVE The authors measured cardiac index in unstable patients after cardiac surgery with the Pressure Recording Analytic Method (PRAM) and compared it with the reference method of thermodilution (ThD) with the pulmonary artery catheter; using the hypothesis that there were no significant differences between the 2 methods. DESIGN A prospective study. SETTING Cardiac surgery intensive car...

To engineer T(h) determinants (THd) to prime help for humoral or cytotoxic T cell responses, we modified ovalbumin [OVA(323-337)] and myoglobin [MYO(106-118)] eliciting T(h)1 and T(h)0 cytokine profiles respectively. Residues along the sequence of both THd were replaced with amino acids representative of different families. Replacements at positions P-1 and P5 pointing to the TCR in both THd af...

AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes dolabelladienotriol (THD, IC50 = 16.5 µM), (6R)-6-hydroxydichotoma-3,14-diene...

In this paper, we investigate the parameters affecting Total Harmonic Distortion (THD) and Power Supply Rejection Ratio (PSRR) in PWM Class D Amplifiers (CDAs) on the basis of linear models with feedback. From our mathematical analysis, we show that the THD of a PWM Class D amplifier with feedback can be improved by increasing the gain of the integrator through adding another amplifier at the o...

This paper proposes a generalized space vector pulse width modulation (SVPWM) technique for hybrid multilevel inverters for minimizing total harmonic distortion (THD). The proposed method easily determines the actual location of the instantaneous reference space vector and the corresponding switching sequence of a multilevel inverter. The proposed algorithm offers a novel method for minimizing ...

The power quality in electrical energy systems is very important and harmonic is the vital criterion. Traditionally Fast Fourier Transform (FFT) and Discrete Fourier Transform (DFT) have been used for the harmonic distortion analysis and in the literature harmonic estimations have been made using different methods. As an alternative method, this paper suggested using Support Vector Machine (SVM...