Beta thalassemia dominant results from mutations in the β globin chain gene resulting in the production of elongated, highly unstable beta globin chains. Several such mutations have been described and in a heterozygous state they may confer a phenotype more severe than that of β thalassemia trait and lead to a clinical syndrome of thalassemia intermedia and its associated complications such as ...

Background. Coexistence of iron deficiency anemia (IDA) and beta thalassemia trait (BTT) has been the topic of few studies. However, no study from our country was found evaluating the effect of iron therapy in patients with concomitant IDA and BTT. Methods. Over a period of two years, 30 patients with concomitant IDA and BTT were included. All the patients had a complete blood count, serum iron...

Preliminary findings from these studies were presented at the 37th Annual Meeting of the American Federation for Clinical Research, 10-12 May 1980, in Washington, D. C. (Clin. Res. 28: 305A). Address all correspondence to Dr. Benz, Hematology Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. 06510. Received for publication 15 August 1980 and in revis...

Cite this article: Kattamis C (2017) The Normal HbA2 Hematological Phenotype of β-Thalassemia Trait. Problems in Detection and Measures to Improve Sensitivity of Screening Tests. J Hematol Transfus 5(2): 1068. *Corresponding author Christos Kattamis, Thalassemia Unit 1st Department of Pediatrics, National Kapodistrian University of Athens, “Aghia Sophia” Children Hospital, Athens, Greece, Email...

INTRODUCTION Thalassemia and iron deficiency may both result in hypochromic microcytic anemia. Hematological algorithms that differentiate the two are mainly established in adult selected diagnostic groups. We aimed at creating an algorithm applicable in the presence of children, hemoglobin variants, and iron deficiency. METHODS Our study material constituted blood samples referred during 1 y...

Suntaree Apibal, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok 10400 (Thailand) The presence of fetal red cells (F cells) in the maternal circulation is an indicator of a fetomaternal hemorrhage which may subsequently lead to hemo-lytic disease of the newborn [1]. However, a small amount of F cells were found in some normal adults [4] whereas the increase in hemogl...

A flow injection (FI)-reduced volume column system was developed for hemoglobin (Hb) typing to be used as an initial screening method for thalassemia. The column was packed with 140 microl diethylaminoethyl (DEAE)-Sephadex A-50 ion exchange beads. Hb can be separated using Tris-HCl buffer solution with pH gradient 8.5-6.5 and then monitored spectrophotometrically at 415 nm. The hemolysate of 40...

100 patients with beta-thalassemia trait, comprised of 55 men and 45 women, participated in a study to measure serum lipoproteins. The results were compared with the data obtained from 100 control subjects of the same age and sex. A significantly lower level of mean serum total cholesterol and LDL cholesterol, and a much higher level of HDL cholesterol were obtained in beta-thalassemia trai...