نتایج جستجو برای: th17 cells
تعداد نتایج: 1385860 فیلتر نتایج به سال:
Th17 cells are key players in defense against pathogens and maintaining tissue homeostasis, but also act as critical drivers of autoimmune diseases. Based on single-cell RNA-seq profiling of pathogenic versus nonpathogenic Th17 cells, we identified protein C receptor (PROCR) as a cell surface molecule expressed in covariance with the regulatory module of Th17 cells. Although PROCR expression in...
Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis but can induce autoimmunity. The mechanisms implicated in balancing "pathogenic" and "non-pathogenic" Th17 cell states remain largely unknown. We used single-cell RNA-seq to identify CD5L/AIM as a regulator expressed in non-pathogenic, but not in pathogenic Th17 cells. Although CD5L does not a...
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation. Recent evidence, supporting the notion of a functional and phenotypic instability of Th17 cells, has shown that Th17 differentiate into type 1 regulatory...
Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in Behçet's disease (BD). T helper (Th) cells have a central role in modulating immune responses. Traditionally, BD is regarded as a Th1-mediated inflammatory disease. Recently, Th17 cells were identified as a new subset of Th cells unrelated to Th1 or Th2 cells, and several cyt...
atopic dermatitis (ad) is a heterogeneous disease with regard to clinical phenotype and natural history. we investigated t cell subtypes and cytokine responses in peripheral blood and skin lesions of ad patients with various sensitivities. immunological studies were performed in 27 subjects: 9 house dust mite (hdm)-sensitized; 6 subjects with sensitizations other than hdm; 7 non-allergic ad pat...
Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed ...
Although Th17 cells play critical roles in the pathogenesis of many inflammatory and autoimmune diseases, their prevalence among tumor-infiltrating lymphocytes (TILs) and function in human tumor immunity remains largely unknown. We have recently demonstrated high percentages of Th17 cells in TILs from ovarian cancer patients, but the mechanisms of accumulation of these Th17 cells in the tumor m...
Interleukin-23 (IL-23) is required for inflammatory Th17 cell function in experimental autoimmune encephalomyelitis (EAE), and IL-23 blockade reduces the number of effector Th17 cells in the CNS. We report that pro-inflammatory Th17 cells express high integrin β3 that is IL-23 dependent. Integrin β3 was not upregulated on all activated T cells; rather, integrin β3 was upregulated along with its...
To assess the effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes URSA patients. Ninety-six eligible patients were randomly divided into control experimental groups (n=48). Active was performed for group, while group treated immunotherapy. Counts peripheral blood helper T lymphocytes 17 (Th17) regulatory (Treg), ...
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