PURPOSE To create a standardized method for evaluating the video recordings of patients self-instilling eye drops and to determine the level of agreement of eye drop instillation efficacy, safety and efficiency ratings by three masked graders. DESIGN Prospective cross-sectional study. PARTICIPANTS 78 patients with open-angle glaucoma or ocular hypertension who had at least 6 months of exper...

This report describes a case of a 72-year-old Caucasian woman presenting with a large neurotrophic keratitis with a large persistent epithelial defect, with a longest linear diameter of 7 mm and greatest perpendicular width of 5 mm, affecting epithelium, Bowman membrane, and anterior stroma. Corneal disease was resistant to conventional treatment and classified as stage 2 according to Mackie cl...

PURPOSE To evaluate the safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% fixed-combination (DTFC) eye drops to brinzolamide 1.0%/timolol maleate 0.5% fixed-combination (BTFC) eye drops in patients with primary open-angle glaucoma or ocular hypertension. METHODS A total of 35 eyes of 35 patients with primary open-angle glaucoma or ocular hypertension using DTFC eye d...

OBJECTIVE To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). METHODS A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoraci...

OBJECTIVE To compare the effectiveness of dexamethasone and diclofenac sodium eye drops in the resolution of inflammation following phacoemulsification surgery with posterior chamber intraocular lens implants. STUDY DESIGN Quasi-experimental study. PLACE AND DURATION OF STUDY Ophthalmology Department, PNS Shifa Hospital, Karachi, from June 2006 to March 2007. METHODOLOGY One hundred subje...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

et al. [3] introduced the term ‘tarsoconjunctival crypts.’ They postulated that the tarsal conjunctiva sequestration of bacteria was initiated by trauma caused either by inf lammation from Stevens-Johnson syndrome or by mechanical abrasion from nocturnal lid eversion. Partial sloughing of the tarsal conjunctiva and subsequent re-epithelization over a lamellar layer of epithelium formed an epith...

AIMS To investigate the intraocular penetration of vancomycin eye drops and to compare the conventional method of drop instillation to the lower cul de sac with applying drops to the medial canthus with closed lids. METHODS This prospective randomised trial evaluated 53 eyes of 53 patients who had undergone extracapsular cataract extraction (ECCE) with intraocular lens implantation. Vancomyci...

Purpose: To evaluate the influence of commonly used eye drops on contrast sensitivity (CS). Design: Prospective study. Participants: One hundred twenty volunteers were enrolled. Methods: The CS of ophthalmologically healthy individuals was evaluated at baseline examination before the instillation, 20 and 40 minutes after the instillation of diclofenac sodium and commonly used anti-glaucoma eye ...