PURPOSE Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. METHODS We carried out longitudinal measure...

Background: Spinal cord injury (SCI) is a traumatic or nontraumatic injury that can leads to loss of functions such as feeling or mobility along with permanent and debilitating influences on the patient’s quality of life. Patients with SCI have weakened sexual function and a distinctive sperm profile described by normal to high sperm concentrations and unusually low sperm mobility. The reason o...

BACKGROUND Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum, is in good correlation with the latter, indicating that salivary testosterone provides a reliable method for determination of serum free test...

OBJECTIVE To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges. DESIGN Pilot study. SETTING University-based hospital. PATIENT(S) Ten bilaterally oophorectomized women. INTERVENTION(S) Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg). MAIN OUTCOME MEASURE(S) Total testosterone, andros...

BACKGROUND Fetal exposure to testosterone has been implicated in programming childhood behaviour, but little is known about the determinants of fetal testosterone concentrations. AIMS To investigate the relation between fetal testosterone and maternal and fetal cortisol. METHODS Clinically indicated blood samples taken from 44 human fetuses (mean gestational age 27 weeks, range 15-38), toge...

Women are generally more risk averse than men. We investigated whether between- and within-gender variation in financial risk aversion was accounted for by variation in salivary concentrations of testosterone and in markers of prenatal testosterone exposure in a sample of >500 MBA students. Higher levels of circulating testosterone were associated with lower risk aversion among women, but not a...

This study reports on findings of a pilot of community-based distribution (CBD) of injectable contraceptives in two local government areas (LGAs) of Gombe State, Nigeria. From August 2009 to January 2010, the project enrolled, trained and equipped community health extension workers (CHEWs) to distribute condoms, oral and injectable contraceptives in communities. The project mobilized communitie...

Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate injected weekly) with or without resistance training (45 minutes three times we...

Testosterone glucuronide (unlabeled and labeled) was synthesized and injected into three normal men, one pregnant woman, and one child. In addition to testosterone glucuronide itself, several urinary metabolites were isolated. Only 5&androstane steroids were obtained. More 5/!Landrostane-3or, 17/3-diol than Sfl-androsterone was found. Meanwhile, a testosterone tracer gave Sa-metabolites, and mo...

objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...