نتایج جستجو برای: testicular toxicity
تعداد نتایج: 138643 فیلتر نتایج به سال:
Previous studies on the reproductive toxicity of boric acid have indicated that male rodents suffer testicular atrophy after treatment. There were, however, no studies of the potential effects on female fertility or on the neonate. In addition, no study described the development of the testicular lesion, thought to be related to the mechanism of toxicity. A Reproductive Assessment by Continuous...
Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated Dose Studies in Rats
Nitrofurazone (NF) has been previously demonstrated to induce testicular toxicity with 4 weeks of oral administration in rats, ln the present study, rats were administered NF to assess whether testicular toxicity becomes evident with a 2-week administration period, Male Sprague-Dawley rats were administered oral doses of NF at 50 mgfkg fbr 2 or 4 weeks. Another group was administered NF at 100 ...
Background:Gossypol is a yellow toxic pigment from the cottonseed that can cause acute or chronic toxicity in humans and animals by affecting the testicular tissues. Nowadays cottonseed is used as food supplement for ruminants specially the sheep. In this study, two different stem cell lines of testicular tissue including GC1-spg (mouse testis) and SFTF-PI43 (sheep testis) cells were used to ev...
Background and purpose: Cerium oxide nanoparticles (CNPs) are widely used as a catalyst in industry and as an antioxidant in applied nanomedicine. The biological effect of CNPs exposure on testis tissue is not known. The objective of this study was to evaluate the effect of CNPs on testis in mice model. Materials and methods: In this experimental study, CNPs were administered intraperitoneally...
Background: Sertraline is prescribed mainly for the treatment of patients with depression. However, this drug is known to have toxic effects on the male germ cells. Therefore, this study was designed to examine the ameliorative effects of curcumin on the sertraline-induced male reproductive toxicity. Methods: Thirty-two male Wistar rats were randomly divided into four groups of eight each. The...
Di(2-ethylhexyl) phthalate (DEHP) produced seminiferous tubular atrophy and reductions in seminal vesicle and prostate weight in 4-week-old, but not in 15-week-old rats. Di-n-pentyl phthalate (DPP) did produce atrophy in the older rats but this developed more slowly than in young animals. Coadministration of testosterone or gonadotrophins did not protect against phthalate-induced testicular tox...
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