With the nuclear exchange assay and the nuclear retention assay it is shown that the androgen insensitivity of Tfm mice is probably due to a defect of the nuclear acceptor sites for the testosterone receptor complex. Further on the results obtained point strongly to the possibility that hormone free androgen receptor is localized in the nuclei and in the cytoplasma according to the "equilibrium...

Arthropod sex ratios can be manipulated by a diverse range of selfish genetic elements, including maternally inherited Wolbachia bacteria. Feminization by Wolbachia is rare but has been described for Eurema mandarina butterflies. In this species, some phenotypic and functional females, thought to be ZZ genetic males, are infected with a feminizing Wolbachia strain, wFem. Meanwhile, heterogameti...

Testicular feminisation syndrome in a neonate was confirmed by cytogenetic studies. Karyotype analysis in 2 phenotypically female siblings showed the presence of the disorder in the 2 year old sibling. Subsequently a fourth phenotypically female sibling showed the disorder.

Two commentaries explore the question of how much information should be disclosed to a 16-year-old female patient about the genetic abnormality, testicular feminization (XY genotype), which renders her infertile. She has presented with precancerous testes that require surgical removal and also needs an operation on her vagina in order for her to be able to engage in intercourse. Minoque and T...

We treated 2 different types of intersexual patients who underwent a vaginoplasty with the pudendal-thigh flap. One was a female with testicular feminization syndrome for whom we reconstructed the total vagina with a pudendal-thigh flap, and the other was a female with an adrenogenital syndrome for whom we enlarged the introitus of the vagina with the same approach. There were no complications ...

introduction: complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 xy karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives. discussion: our medline search revealed that this is the first reported case of bilateral sertoli–leydig cell tumor (slct) in androgen insensi...

A collection of neurons in the upper lumbar spinal cord of male rats projects to the lower lumbar spinal cord, releasing gastrin-releasing peptide (GRP) onto somatic and autonomic centers known to regulate male sexual reflexes such as erection and ejaculation. Because these reflexes are androgen dependent, we asked whether manipulating levels of androgen in adult rats would affect GRP expressio...

Sows were randomly selected and assigned to either the Hurnik-Morris system (HM; n = 59) or a conventional gestation crate system (GC; n = 90) before breeding. The HM system provides housing for sows in small groups. All sows were bred to Duroc x Hampshire commercial boars. A common farrowing barn with 18 farrowing crates was used for the HM and GC sows. The HM sows had less (P<.001) backfat at...