The synthesis 2-tert-butyl-4-methylphenol is of great significance because its wide application in industry, and the development a highly efficient catalyst necessary for alkylation p-cresol tert-butyl alcohol. Here, an mild method was established. Caprolactam chosen as hydrogen-bonding acceptor; p-toluenesulfonic acid employed donor, deep eutectic solvent (DES) prepared to catalyze reaction. s...

The MnBr2 complex of N2,N6-bis-(di-tert-butyl-phosphan-yl)pyridine-2,6-di-amine (1·MnBr2) co-crystallizes with 5.69% of the monophosphine oxide analogue (1O·MnBr2) and two tetra-hydro-furan (THF) mol-ecules, namely [N2,N6-bis-(di-tert-butyl-phosphan-yl)pyridine-2,6-di-amine]-dibromido-manganese(II)-[bis-(di-tert-butyl-phosphan-yl)({6-[(di-tert-butyl-phosphan-yl)amino]-pyridin-2-yl}amino)-phosph...

Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and ...

O-tert-Butyltyrosine (Tby) is an unnatural amino acid that can be site-specifically incorporated into proteins using established orthogonal aminoacyl-tRNA synthetase/tRNA systems. Here we show that the tert-butyl group presents an outstanding NMR tag that can readily be observed in one-dimensional (1)H NMR spectra without any isotope labeling. Owing to rapid bond rotations and the chemical equi...

Recent experimental and theoretical studies shed new light on the ultrafast photochemical decomposition of organic peroxides, R1C(O)O–OR2. This reaction both is of fundamental interest, directed toward a detailed understanding of unimolecular processes, and of practical relevance because of the widespread use of peroxides as initiators in free-radical polymerization. An overview is given on pic...

The effects of feeding p-methoxyphenol, benzyl isothiocyanate, coumarin, alpha-angelicalactone, 2-tert-butyl-4-hydroxyanisole, and 3-tert-butyl-4-hydroxyanisole on the glutathione S-transferase activity and sulfhydryl levels of esophagus and small bowel mucosa of ICR/Ha mice have been investigated. p-Methoxyphenol, benzyl isothiocyanate, coumarin, and 2-tert-butyl-4-hydroxyanisole increased glu...

Iron(II) complexes of the tetradentate amines tris(2-pyridylmethyl)amine (TPA) and N,N'-bis(2-pyridylmethyl)-N,N'-dimethylethane-1,2-diamine (BPMEN) are established catalysts of C-O bond formation, oxidising hydrocarbon substrates via hydroxylation, epoxidation and dihydroxylation pathways. Herein we report the capacity of these catalysts to promote C-N bond formation, via allylic amination of ...

Taking into consideration the biological activity of the only natural products containing a 1,2,4-oxadiazole ring in their structure (quisqualic acid and phidianidines A and B), the natural product analogs 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-2,5-dione (4) and 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-pyrrole-2,5-dione (7) were synthesized starting from 4-(3-tert-...