The effects on mucopolysaccharide synthesis in isolated embryonic rat hearts of in vivo and/or in vitro 6-aminonicotinamide, dietary-induced folic acid deficiency, aminopterin, and trypan blue were investigated using uptake of 35S-sodi~m sulfate to measure the rate of mucopolysaccharide synthesis. Intraperitoneal injection of 6-aminonicotinamide on day 11 of gestation caused inhibition of mucop...

In the original version of this Article, there is a typographical error in Affiliation 1 which was incorrectly listed as '

In view of the great number of teratogenic factors known and the vast array of congenital defects, disorders and syndromes, it would probably be a waste of time to search for unifying mechanisms and principles in abnormal development. Instead, therefore, I shall describe a selection of teratogens and their consequences, and try to arrange them in a certain hierarchy based on a simplified model ...

SUMMARY – Congenital malformations of the head and neck are a wide and extremely heterogeneous group because this region contains parts of almost all organ systems. These malformations range in their importance and severity from purely cosmetic defects and minor disturbances to lethal anomalies. They can be isolated or occur as a component of a sequence, syndrome or chromosomal disorder. Some o...

L I T T L E information is available in the literature on the susceptibility of the hamster embryo to teratogens. Desoxycorticosterone acetate apparently has some teratogenic activity (Tedford & Risely, 1950), but the degree and type of abnormality produced by this agent in the hamster have not been recorded. Orsini (1952) has described naturally-occurring urogenital anomalies which appear in f...

Behavioral effects have been found to result from the prenatal administration of substances known to be teratogenic to the CNS. These effects occur at dose levels lower than those producing gross malformations and when the agent is administered at times other than that optimal for CNS relevant technique for detecting adverse consequences of prenatal exposure to drugs and chemicals. Behavioral t...