BACKGROUND We examine the clinical significance and biomarkers of tissue plasminogen activator (tPA)-catalyzed clot lysis time (CLT) in patients with intermediate-risk pulmonary embolism (PE). METHODS Platelet-poor, citrated plasma was obtained from patients with PE. Healthy age- and sex-matched patients served as disease-negative controls. Fibrinogen, α2-antiplasmin, plasminogen, thrombin ac...

BACKGROUND The optimal antithrombotic therapy to accompany tenecteplase in cases of acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We undertook a prespecified pooled analysis of data from the ASSENT-3 and ASSENT-3 PLUS trials. METHODS We created a combined database of the 2040 and 818 patients who received enoxaparin in ASSENT-3 and ASSENT-3 PLUS, respectively, and ...

BACKGROUND Hemorrhagic complications are quite common in the rare cases where thrombolysis is performed. Ischemic stroke in the aftermath of thrombolysis for a ST elevation myocardial infarction is a very rare and paradoxical complication. With these observations in mind we report two interesting cases of ischemic stroke which occurred after fibrinolytic therapy with tenecteplase for a ST eleva...

Parity and time invariance violating forces produce collective Pand Todd moments in nuclei with static octupole deformation. Collective Schiff moment, electric octupole and dipole and also magnetic quadrupole appear due to the mixing of rotational levels of opposite parity and can exceed singleparticle moments by more than a factor of 100. This enhancement is due to two factors, the collective ...

a common complication of prosthetic heart valves is thrombosis. although the incidence of prosthetic valve thrombosis (pvt) in the tricuspid position is high, there are not enough data on the management of it, in contrast to left-sided pvt. here, we describe three cases of tricuspid pvt with three different management approaches: thrombolytic therapy; close observation with oral anticoagulants;...

To the Editor: In the Pulmonary Embolism Thrombolysis (PEITHO) study (April 10 issue),1 a bolus of unfractionated heparin was withheld from 303 patients because they had just received subcutaneous low-molecular-weight heparin or fondaparinux. Low-molecular-weight heparin in particular has a slow onset of action, taking 4 to 6 hours to reach full effect.2 This delay in the effect of treatment ma...