نتایج جستجو برای: tem cells
تعداد نتایج: 1418823 فیلتر نتایج به سال:
In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions (paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that TEM is mostly paracellular. The mechanisms that control the route of leukocyte TEM remain unknown. Here we tested the hypothesis that elevated intercellular adhesion molecule-1 (ICAM-1) expression regulates the l...
Human effector memory CD4 T cells may transmigrate across endothelial cell (EC) monolayers either in response to inflammatory chemokines or in response to TCR recognition of Ag presented on the surface of the EC. The kinetics, morphologic manifestations, and molecular requirements of chemokine- and TCR-driven transendothelial migration (TEM) differ significantly. In this study, we report that, ...
Broadside-coupled striplines in a shield are basic guiding structures in coupled transmission line (CTL) cells that are important in EMI/EMC applications [1]–[3]. The CTL cells exhibit good performance in terms of field uniformity and bandwidth. The CTL cells consist of uniform and tapered sections. Higher-order TE and TM wave propagation along the uniform section was studied in [4]. Higher-ord...
In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions (paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that TEM is mostly paracellular. The mechanisms that control the route of leukocyte TEM remain unknown. Here we tested the hypothesis that elevated intercellular adhesion molecule-1 (ICAM-1) expression regulates the l...
The Rap1 GTPase is a master regulator of cell adhesion, polarity, and migration. We show that both blocking Rap1 activation and expressing a constitutively active form of Rap1 reduced the ability of B16F1 melanoma cells to extravasate from the microvasculature and form metastatic lesions in the lungs. This correlated with a decreased ability of the tumor cells to undergo transendothelial migrat...
In recent years, in situ transmission electron microscopy (TEM) studies have been performed to investigate the electrochemically driven phase conversions in lithium-ion batteries. However, most of these studies primarily focused on non-volatile environments and lacked information on interfaces between commercially used organic liquid electrolytes and battery electrodes. Furthermore, due to limi...
Introduction CD8 T cell response comprises effector and memory T cells. Effector CD8 T cells become terminally differentiated and are eliminated by apoptosis. Memory CD8 T cells encompass central (TCM) and effector memory T cells (TEM). TCM display a higher proliferative ability, express a higher level of CD62L and are superior in their protection against viral and bacterial challenges and medi...
The chemokine stromal-derived factor-1A (SDF-1A/CXCL-12) and its receptor, CXCR4, play a crucial role in adhesion and transendothelium migration (TEM) of prostate cancer cells. We tested the hypothesis that enhanced expression of CXCR4 in prostate cancer cells is dependent upon SDF-1A-mediated activation of nuclear factor-KB (NF-KB). SDF-1A increased the CXCR4 mRNA and protein expression in PC-...
RECENT STUDIES HAVE DEMONSTRATED that the immune system plays an important pathophysiological role in diseases of the kidney and the vasculature. In particular, the role of T lymphocytes in the development and maintenance of renal (1, 3, 4, 5) and cardiovascular disease (3, 5, 6, 9) has been a topic of intense study in recent years. Pharmacological and genetic methods in experimental animals ha...
Kanai, T., K. Tanimoto, Y. Nemoto, R. Fujii, S. Makita, T. Totsuka, and M. Watanabe. Naturally arising CD4 CD25 regulatory T cells suppress the expansion of colitogenic CD4 CD44CD62L effector-memory T cells. Am J Physiol Gastrointest Liver Physiol 290: G1051–G1058, 2006. First published December 22, 2005; doi:10.1152/ajpgi.00429.2005.—Naturally arising CD4 CD25 regulatory T (TR) cells have been...
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