BACKGROUND The aims of this study were to compare results from a Taiwanese sub-study of the GLOBE 2303 telbivudine study and evaluate the HBV DNA kinetics. METHODS Forty-one Taiwanese patients were treated for an additional 2 years with telbivudine. Efficacy endpoints were the same as the GLOBE study. The correlations of reductions in HBV DNA levels at Week 24 were evaluated. RESULTS All 7 ...

The treatment of HBV infection in patients with HIV co-infection presents several peculiar features: some drugs active against HBV are also active against HIV. This precludes their use in monotherapy in HIV-HBV co-infected patients due to the potential risk of selecting HIV-resistant strains. Telbivudine seemed to be a candidate for exclusive anti-HBV therapy because it exerts no significant in...

K. R. Paap and L. S. Johansen (1994) proposed that word frequency effects do not occur on a lexical decision task (LDT) when postmasked target exposure duration is sufficiently brief because such a task prevents verification--their hypothesized locus of the word frequency effect. In making this assertion, they proposed that the activation interpretation of A. R. Dobbs, A. Friedman, and J. Lloyd...

In a lexical-decision task (LDT), Hino and Lupker (1996) reported a polysemy effect (faster response times for polysemous words [e.g., BANK]), and attributed this effect to enhanced feedback from the semantic system to orthographic units, for polysemous words. Using the same task, Pexman, Lupker, and Jared (in review) reported a homophone effect (slower response times for homophonic words [e.g....

Semantic richness is a multidimensional construct that can be defined as the amount of semantic information associated with a concept. OBJECTIVE To investigate neurophysiological correlates of semantic richness information associated with words and its interaction with task demands. METHOD Two different dimensions of semantic richness (number of associates and number of semantic neighbors) ...

P. M. Pexman, S. J. Lupker, and D. Jared (2001) reported longer response latencies in lexical decision tasks (LDTs) for homophones (e.g., maid) than for nonhomophones, and attributed this homophone effect to orthographic competition created by feedback activation from phonology. In the current study, two predictions of this feedback account were tested: (a) In LDT, observe homophone effects sho...

UNLABELLED BECKGROUND: Evaluate the efficacy and safety of telbivudine during the 2nd and 3rd trimester of pregnancy in intrauterine transmission of hepatitis B virus (HBV). Based on the principle of Cochrane systematic reviews, a database was constructed from Medline, EMBASE, Cochrane Library, the US National Science Digital Library (NSDL), the China Biological Medicine Database (CBM-disc), an...

In the current study, participants performed an ongoing lexical decision task (LDT) in which they had to classify letter strings as words or non-words. In intention conditions, they also had to encode a postponed intention to remember to make a different response if a pre-specified cue appeared. Attempting to replicate an important finding from Cohen et al. (2008), the interest was in examining...