AIMS Diastolic dysfunction in patients with heart failure has prognostic relevance, possibly because of its relationship with worsening haemodynamic status. In the quest for simpler indexes of haemodynamic status in patients, brain natriuretic peptide (BNP) levels have been proposed as a surrogate of diastolic function. To date, the value of combining BNP levels with non-invasive haemodynamic m...

INTRODUCTION Open chest surgery (thoracotomy) is considered the most painful of surgical procedures. Forceful wound retraction, costochondral dislocation, posterior costovertebral ligament disruption, intercostal nerve trauma and wound movement during respiration combine to produce an acute, severe postoperative pain insult and persistent chronic pain many months after surgery is common. Three ...

Can we improve the modeling of urban land surface processes with machine learning (ML)? A prior comparison models (ULSMs) found that no single model is 'best' at predicting all common fluxes. Here, develop an neural network (UNN) trained on mean predicted fluxes from 22 ULSMs one site. The UNN emulates output accurately. When compared to a reference ULSM (Town Energy Balance; TEB), has greater ...

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We examined the effect of 17beta-estradiol (E2) and soy isoflavones' exposure on morphogenesis and global gene expression in the murine mammary gland. Three exposure regimens were applied: isoflavones added to the diet throughout either the lactational period (via the dams) or the postweaning period and E2 administered orally during the lactational period. Whole mounts of mammary glands were ev...

The MODerate Resolution Imaging Spectroradiometer (MODIS) is one of the key instruments for the NASA s Earth Observing System (EOS). The MODIS ProtoFlight Model (PFM) was launched on-board the EOS Terra spacecraft on December 18, 1999 and has been providing the science community and public users global data sets for the study of the land, oceans, and atmosphere for more than two and a half year...

The Ron receptor tyrosine kinase regulates multiple cellular processes and is important during mammary gland development and tumor progression. Hepatocyte growth factor-like protein [HGFL] is the only known ligand for the Ron receptor and recent studies have identified major roles for HGFL during breast cancer metastasis. Understanding the functional importance HGFL during mammary gland develop...

BACKGROUND Impedance cardiography (ICG) has been used extensively to estimate stroke volume (SV) and cardiac output (CO) from changes of thoracic electrical bioimpedance (TEB). However, studies comparing ICG with reference methods have questioned the reliability of this approach. Electrical velocimetry (EV) provides a new algorithm to calculate CO from variations in TEB. As the transoesophageal...