Interleukin (IL)-17A is expressed in the tumor microenvironment where it appears to contribute to tumor development, but its precise role in tumor immunity remains controversial. Here, we report mouse genetic evidence that IL-17A is critical for tumor growth. IL-17A–deficientmice exhibited reduced tumor growth,whereas systemic administration of recombinant mouse IL-17A promoted the growth of he...

C ardiovascular disease has become t he major cause of death in the U.S. and other Western countries not just because people are living longer but because some unknown aspects of modern life are increasing the incidence of atherosclerosis, the chronic arterial disorder that is the major cause of heart attacks and strokes. We cannot identify those aspects until we know the true nature of the cha...

We present and study an agent-based model of TCell cross-regulation in the adaptive immune system, which we apply to binary classification. Our method expands an existing analytical model of T-cell cross-regulation [28] that was used to study the self-organizing dynamics of a single population of T-Cells in interaction with an idealized antigen presenting cell capable of presenting a single ant...

Purpose: Terminal deoxynucleotidyl transferase(TdT) is a DNA polymerase that is present in immature pre-B and pre-T cells. TdT inserts N-nucleotides to the V (D) J gene segment during rearrangements of genes, therefore, it plays a vital role in the development and variation of the immune system in vertebrates. Here we evaluated the relationship between cytokines like interleukin-2 (IL-2), inter...

Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo. Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×10/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of perit...

Multipotent mesenchymal stromal cells (MSCs) possess immunomodulatory properties. The effect of MSCs on the crucial cellular immunity compartment – T-cells is of a special interest. It is known that MSC tissue niche and expected milieu of their interaction with Tcells are characterized by low oxygen concentration, whereas the in vitro experiments usually are carried out at a much higher ambient...

CD4 CD25 T-cells can be used to interfere with spontaneous autoimmune diseases such as type 1 diabetes. However, their low frequency and often unknown specificity represent major obstacles to their therapeutic use. Here we have explored the fact that ectopic expression of the transcription factor Foxp3 can confer a suppressor phenotype to naı̈ve CD4 T-cells. We found that retroviral transduction...

NABEYAMA, A. and OGATA, T. Cytological Studies on the Eaterochrounafin Cells in the Intestinal Metaplasia. Tohoku J. exp. Med., 1971, 105 (4),355-363 The enterochromaffin cells (Ec-cells) in the normal and pathological antral mucosa of the human stomach were examined. It was clarified that the Ec-cells are observed only in the mucosa with intestinal metaplasia, and never in the normal mucosa. W...

OBJECTIVE To investigate a role of Vitamin D in the pathogenesis of preeclampsia (PE), and to discern any potential benefits of Vitamin D supplementation on hypertension in the RUPP rat model of PE. STUDY DESIGN Blood and placentas from normal pregnancies (NP) and PE were collected following elective cesarean delivery without evidence of infection. Circulating Vitamin D was extracted by HPLC ...

abstract background and aims: vitamins are essential constituents of our diet that longley have been known to influence the immune system. vitamin d3 and b9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(oh)2d3 metabolizing enzymes and vitamin d receptor (vdr) are present in many cell ty...