The effects of six flavonoids viz., apigenin, genistein, morin, naringin, pelargonidin and quercetin on the susceptibility of low-density lipoprotein (LDL) to oxidative modification were investigated. Flavonoids were added to plasma and incubated for 3 hr at 37 degrees C, and the LDL fraction was separated by ultracentrifugation. Oxidizability of LDL was estimated by measuring conjugated diene ...

OBJECTIVE To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of shor...

This study aimed to evaluate the effect of Spirulina platensis and moderate exercise on oxidative stress and lipid profiles in the rats. Forty male Wistar rats were allocated to the following 10-week treatments, three times a week: exercise (E, 30 min swimming), S. platensis (SP, 26 mg/Kg); exercise and Spirulina (ES); and control (C). Outcomes were Thiobarbituric Acid Reactive Substances (TBAR...

Glucose-6-phosphate dehydrogenase (G6PD) deficient subjects are vulnerable to oxidative stress. Quercetin, a flavonoids, has been employed as a potent oxygen-free radical scavenger in order to assess the protective effects of quercetin against H2O2-induced oxidative damage in G6PD-deficient and normal human erythrocytes. Erythrocytes of G6PD-deficient (n = 10) and normal (n = 10) subjects were ...

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels i...

Tubular dysfunction is a hallmark of severe leptospirosis. Antimicrobial therapy is thought to interfere on renal involvement. We evaluated the expression of a proximal tubule type-3 Na+/H+ exchanger (NHE3) and a thick ascending limb Na+-K+-2Cl(-) cotransporter (NKCC2) in controls and treated hamsters. Animals infected by a serovar Copenhageni isolate, were treated or not with ampicillin (AMP) ...

The authors are affiliated with the Dept. of Animal Science, Iowa State Univ., Ames, IA 50011-3150. Direct inquiries to Dr. D. U. Ahn. ABSTRACT Irradiation dose affected production of volatiles in vacuumand aerobic-packaged cooked pork sausage, but its effect on TBARS was minor. Storage increased production of volatiles and changed their composition only in aerobic-packaged sausage. Among volat...

Methanolic seed extract of Nelumbo nucifera was partitioned with chloroform and was investigated for its antioxidant and anticataleptic effects in the haloperidol-induced catalepsy rat model by measuring various behavioral and biochemical parameters. Catalepsy was induced by administration of haloperidol (1 mg/kg, ip) in male albino rats. A significant reduction in the cataleptic scores were ob...

Environmental pollution is a growing concern and, more importantly, pollution of the aquatic ecosystem is alarming. Bivalves are commonly used as bio-indicators of marine pollution. In the present study the Perna viridis was exposed to cadmium, copper, lead and zinc concentrations under longterm chronic toxicity for the estimation of biochemical biomarkers. Significant differences in TBARS leve...

Monosodium glutamate (MSG) was administrated subcutaneously to wistar rats for 60 days and circadian rhythms of thiobarbituric acid reactive substances (TBARS) and antioxidants such as superoxide dismutase (SOD), reduced glutathione (GSH), catalase, glutathione peroxidase (GPX) and Vitamin-E were studied. Advanced acrophase of TBARS and delayed acrophase of antioxidants were found in experiment...