Regulation of transcription of human immunodeficiency virus type-1 (HIV-1) requires specific interaction of Tat protein with the trans-activation response region (TAR). Inhibition of replication of HIV-1 has previously been achieved with a TAR decoy, namely a short RNA oligonucleotide that corresponded to the sequence of the authentic TAR RNA. Since TAR RNA has the potential to interact with ce...

Parts of oil spills reach Iranian coastline along the Persian Gulf in the form of tar balls and scattered oilpatches. There are many published reports regarding oil spills reaching northern coasts of the Persian Gulf,but none report on the content of heavy metals associated with petroleum in sediments and plants ofcontaminated areas. This research was conducted to determine and map petroleum- r...

The effects of divalent Mg(2+) on the conformation and dynamics of the stem-loop transactivation response element (TAR) RNA from HIV-1 have been characterized using NMR residual dipolar couplings (RDCs). Order matrix analysis of one bond 13C-1H RDCs measured in TAR at [Mg(2+)]:[TAR] stoichiometric ratios of approximately 3:1 (TAR(3.0Mg)) and approximately 4.5:1 (TAR(4.5Mg)) revealed that Mg(2+)...

HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge...

In a recent Letter [1] (and in ref. [2]), Filipponi, Pancheri and Srivastava report on the construction of a formula for linear Regge trajectories for all quark flavors: α j ¯ i (t) = 0.57 − (m i + m j) GeV + 0.9 GeV 2 1 + 0.2 (m i +m j GeV) 3/2 t, (1) where m i , m j are the corresponding constituent quark masses for the j ¯ i trajectory. As the authors of [1, 2] remark, no unique quark mass c...

a INRA, UR 546 Biostatistics and Spatial Processes, (BioSP), F-84914 Avignon, France b Mediterranean Institute of Oceanology, University of Aix-Marseille II, Parc Scientifique et Technologique de Luminy, Case 901, 13288 Marseille Cedex 9, France c Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Rd, New Brunswick, NJ, USA d Université de la Nouvelle-Calédonie, Laboratoire...

It is well known that the category of super Lie groups (SLG) is equivalent to the category of super Harish-Chandra pairs (SHCP). Using this equivalence, we define the category of unitary representations (UR’s) of a super Lie group. We give an extension of the classical inducing construction and Mackey imprimitivity theorem to this setting. We use our results to classify the irreducible unitary ...

Introduction: Delivered dose of solute removal (assessed by Kt/v) is an important determinant of clinical outcome in chronic dialysis patients. The gold standard for Kt/v is the direct quantification of the removed urea. A new method, ionic dialysance has been suggested and used over the years. This method is faster, less expensive and non invasive. The objective of this study is to determine t...

1.3 THz with NbTiN transmission lines using a normal metal energy relaxation layer M. P. Westig, S. Selig, K. Jacobs, T. M. Klapwijk, and C. E. Honingh K€ olner Observatorium f€ ur Submillimeter Astronomie (KOSMA), I. Physikalisches Institut, Universit€ at zu K€ oln, Z€ ulpicher Straße 77, D-50937 K€ oln, Germany Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of T...

In recent years, several combinatorial problems were introduced in the area of access control. Typically, such problems deal with an authorization policy, seen as a relation UR ⊆ U ×R, where (u, r) ∈ UR means that user u is authorized to access resource r. Li, Tripunitara and Wang (2009) introduced the Resiliency Checking Problem (RCP), in which we are given an authorization policy, a subset of...