نتایج جستجو برای: tadalafil

تعداد نتایج: 951  

Journal: :Archives of neurology 2007
François Giuliano Antonio Sanchez-Ramos Dieter Löchner-Ernst Giulio Del Popolo Natalio Cruz Albert Leriche Giuseppe Lombardi Susanne Reichert Palle Dahl Albert Elion-Mboussa Joaquin Casariego

OBJECTIVE To determine the efficacy and safety of tadalafil when taken on demand by men with erectile dysfunction (ED) secondary to traumatic spinal cord injury (SCI). DESIGN AND SETTING Multicenter, randomized, double-blind, placebo-controlled, flexible dose-titration, parallel-group study in clinical practices in Europe. Patients Enrolled patients had ED secondary to SCI (all spinal levels)...

2017
Granville G. de Oliveira Samer A. H. de Oliveira Paulo Henrique H. Botelho Marcos Aurelio Barboza de Oliveira Ka Bian Ferid Murad

INTRODUCTION Multiple organ failure syndrome (MOFS) is a pathology associated to unspecified and severe trauma, characterized by elevated morbidity and mortality. The complex inflammatory MOFS-related reactions generate important ischemia-reperfusion responses in the induction of this syndrome. Nitric oxide elevation, through the activation of cyclic guanosine monophosphate (cGMP), has the pote...

Journal: :Journal of the American Heart Association 2016
Jessica A Hiemstra Dong I Lee Khalid Chakir Manuel Gutiérrez-Aguilar Kurt D Marshall Pamela J Zgoda Noelany Cruz Rivera Daniel G Dozier Brian S Ferguson Denise M Heublein John C Burnett Carolin Scherf Jan R Ivey Gianmaria Minervini Kerry S McDonald Christopher P Baines Maike Krenz Timothy L Domeier Craig A Emter

BACKGROUND Cyclic guanosine monophosphate-protein kinase G-phosphodiesterase 5 signaling may be disturbed in heart failure (HF) with preserved ejection fraction, contributing to cardiac remodeling and dysfunction. The purpose of this study was to manipulate cyclic guanosine monophosphate signaling using the dipeptidyl-peptidase 4 inhibitor saxagliptin and phosphodiesterase 5 inhibitor tadalafil...

2011
Pei-Rong Ding Amit K. Tiwari Shinobu Ohnuma Jeferson W. K. K. Lee Xin An Chun-Ling Dai Qi-Si Lu Satyakam Singh Dong-Hua Yang Tanaji T. Talele Suresh V. Ambudkar Zhe-Sheng Chen

One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase 5 (PDE-5) inhibitor significantly reverses MDR in ABCB1 overexpressing cancer cells, and its efficacy was greater than that of tadalafil, anoth...

Journal: :The Analyst 2017
Lu Wang Yunfeng Chai Wenquan Zhu Yuanjiang Pan Cuirong Sun Su Zeng

Mutual chiral recognition of four stereoisomers of tadalafil and three pairs of enantiomers of proton pump inhibitors (PPIs) including pantoprazole, lansoprazole, and omeprazole, as well as quantitative analysis of enantiomeric excess is achieved on the basis of the competitive fragmentation of doubly charged trimeric NiII cluster ions. Compared with a singly charged trimeric cluster ion, a dou...

Journal: :The Journal of rheumatology 2009
Elena Schiopu Vivien M Hsu Ann J Impens Jennifer A Rothman Deborah A McCloskey Julianne E Wilson Kristine Phillips James R Seibold

OBJECTIVE Raynaud's phenomenon (RP) is an important clinical feature of systemic sclerosis (SSc) for which consistently effective therapies are lacking. The study was designed to assess the safety, tolerability, and efficacy of tadalafil, a selective, long acting type V cyclic GMP phosphodiesterase (PDE-5) inhibitor, in this clinical syndrome. METHODS We performed a prospective, randomized, d...

Journal: :Al-Azhar International Medical Journal (Print) 2023

Purpose: We aim to evaluate and compare the efficacy safety of Silodosin, Mirabegron, Tadalafil as a medical expulsive therapy (MET) for lower ureteric stones in adults. Material Methods: A total number 150 cases who had unilateral single stone between December 2021 August 2022 were incorporated this prospective randomized comparative study. The patients randomly divided into 3 equal groups. fi...

2015
Yun Chen Yutian Dai

Objective: To clarify the antioxidation role in diabetic ED treatment by a long-term administration of PDE5I. Methods: Three groups of Sprague-Dawley rats were utilized: group N, normal control; group D, streptozotocin (STZ) induced diabetic rats as control; group D + T, STZ induced diabetic rats by the intragastric administration with tadalafil for 8 weeks. Results: ICP/MAP ratio was significa...

Journal: :Asian journal of andrology 2006
Wai Chun Andrew Yip Han-Sun Chiang Jesus Benjamin Mendoza Hui-Meng Tan Man-Kay Li Wei Christine Wang Vladimir Kopernicky

AIM To assess the efficacy and safety of tadalafil in comparison to a placebo, when taken on demand for 12 weeks by East/Southeast Asian men with erectile dysfunction (ED). METHODS This multicenter, randomized, double-blind, parallel group, placebo-controlled study was conducted at 17 centers across East and Southeast Asia between August 2002 and February 2003. Men more than 18 years of age w...

Introduction: Pulmonary arterial hypertension in children has consequences such as right ventricular failure and even death. Recently, the use of phosphodiesterase 5 inhibitors has been taken into account in the treatment of pulmonary hypertension, among which tadalafil is more acceptable by parents and patients due to its single dose per day compared to sildenafil which should be taken 4 times...

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