Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, active pharmaceutical ingredients (APIs) excipients lack flow properties required to meet needs high-speed industrial tablet presses. Therefore, majority DC APIs are modified via processing/co-processing particle engineering techniques boost their properties. Spray drying ...

UNLABELLED Objective(s) : Ibuprofen is a problematic drug in tableting due to its viscoelastic properties. Additionally its high cohesivity results in low flowability. In this study, co-precipitation of ibuprofen with varying concentration of agar and PVP to optimize properties of Ibuprofen was carried out. MATERIALS AND METHODS Co-precipitates of ibuprofen- PVP or agar were prepared by solve...

The influence of the particle size distribution maltodextrin powders with a dextrose equivalent level 29 as well two tableting process variables, namely compression pressure and dwell time, on tensile strength, porosity, pore final tablet was studied. mechanical strength porosity tablets are assessed in relation to powder parameters. Regarding parameter, it show that compaction clearly has more...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...

Since last five decades ago many natural, semisynthetic and synthetic compounds have been explored as excipients for pharmaceutical drug development. In all these compounds starches remain a strong choice because of its high availability, biocompatibility and multifunctional behaviour. Starches are one of the most used pharmaceutical excipient globally[1]. Although maize and potato starch is th...