BACKGROUND AND PURPOSE Fabry disease is a multisystem X-linked disorder characterized clinically by angiokeratoma, corneal and lenticular abnormalities, acroparesthesia, and renal and cardiac dysfunction and stroke. We sought to describe novel neuroimaging characteristics of Fabry disease. METHODS Neuroradiologic records of 104 hemizygous patients with Fabry disease evaluated between 1994 and...

PURPOSE To assess whether contrast-enhanced T1-weighted MR Cholangiography may provide additional information in the evaluation of biliary complications in orthotopic liver transplant recipients. MATERIAL AND METHODS Eighty liver transplant patients with suspicion of biliary adverse events underwent MR imaging at 1.5 T scanner. After acquisition of axial T1-/T2-weighted images and conventiona...

BACKGROUND AND PURPOSE Early assignment of disease progression among patients with X-linked adrenoleukodystrophy (ALD) is critical for the appropriate selection of effective therapy. We evaluated the association between contrast enhancement on T1-weighted spin-echo MR images and disease progression. METHODS Clinical charts of patients with X-linked ALD were reviewed for age, availability of M...

PURPOSE To compare a rapid fluid-attenuated inversion-recovery (FLAIR) sequence with T1-weighted, fast spin-echo proton density-weighted, and T2-weighted images in the evaluation of cerebrovascular disease. METHODS All patients underwent standard T1-, proton density-, and T2-weighted fast spin-echo and fast FLAIR MR imaging at 1.5 T. Images were compared for lesion size, location, and conspic...

Introduction: The routine use of a calibration phantom that fits easily into a breast coil could provide the basis for standardization and patient-specific calibration of breast MRI. Here, we use a phantom to correct the variable flip angles in a T1 measurement. This increases the accuracy of T1 and contrast media concentration measurements obtained with a clinically employed T1-weighted dynami...

conclusion the minimum concentration of triolein emulsion required to increase vascular permeability adequately with minimal brain edema in a cat model was 0.5%. results the lesion hemispheres showed mild hyperintensity due to edema on t2-weighted images, and contrast enhancement on post-contrast t1-weighted images in cats of group 1-5. cers showed statistically significant differences between ...

BACKGROUND AND PURPOSE MR imaging techniques have proved their efficacy in imaging the head and neck region. In this study, we compared T1-weighted, dual T2-weighted, and fat-suppressed MR imaging and unenhanced and contrast-enhanced 3D time-of-flight MR angiography sequences for detection of head and neck paragangliomas. METHODS Thirty-one patients with 70 paragangliomas were examined. Four ...

OBJECTIVES The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas. METHODS Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET ...

BACKGROUND AND PURPOSE Persistently hypointense lesions on T1-weighted MR images have been shown to correlate with the amount of axonal damage and clinical disability in multiple sclerosis (MS) patients. The purpose of this study was to investigate whether diffusion coefficient D(av) and fractional anisotropy (FA) are able to detect quantifiable differences among three groups of focal nonactive...

Spinal MR findings are reported in a patient with progressive myelopathy and intracranial dural arteriovenous fistula draining into spinal veins. Associated with previously reported abnormalities on T1 weighted and T2 weighted images, postcontrast T1 weighted images disclosed diVuse intense enhancement of the cervical cord itself. This enhancement decreased after endovascular treatment. (J Neur...