In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...

Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. In this area, lesions are usually presented as chalazion, dacryocystitis and rarely ulcera...

The authors report a case of a male patient from Bacabal, MA with diffuse cutaneous leishmaniasis (DCL), for at least nine years, with 168 lesions on his body. These were tumour-like nodules with some ulceration. He used pentavalent antimonial (glucantime) and an association of gamma interferon plus glucantime with improvement of the lesions but relapsed later. Recently, pentamidine isethionate...

An 18-year-old female presented with a severe ulcerative lesion on her right ear of 6 weeks duration. Her right ear was edematous and erythematous with a large, painless ulcerative lesion covering a third of the pinna and satellite papular lesions on the posterior. She was diagnosed with chiclero's ulcer. A skin smear stained with Diff-quik showed abundant Leishmania parasites. Chiclero's ulcer...

OBJECTIVES To evaluate the in vitro leishmanicidal activity of nine flavonoid derivatives from Delphinium staphisagria against L. infantum and L. braziliensis. DESIGN AND METHODS The in vitro activity of compounds 1-9 was assayed on extracellular promastigote and axenic amastigote forms and on intracellular amastigote forms of the parasites. Infectivity and cytotoxicity tests were carried on ...

abstract background glucantime is the first line agent for treatment of cutaneous leishmaniasis (cl). it has adverse effects on blood elements. this research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. methods this clinical trial was done at nikpour clinic, yazd, iran. blood samples were collected from patients diagnosed with cl b...

background: various responses and different prognosis to specific treatment in different patients from one hand, and importance of ifn-γ producer cells on the other hand impressed us to study tc1. methods: the study was conducted in ghaem medical center and bu-ali research institute, mashhad university of medical sciences, iran from 2001 to 2002. lymphocytes of 36 patients were counted and cult...

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...

background and objectives: kerman province, especially city of bam in the southeast part of iran, is epidemics for dry type cutaneous leishmaniasis (dtcl). this study was conducted to compare the effect of different treatments on parasite dna load following therapies using real-time pcr method. materials and methods: fifteen patients were divided into three groups under therapy with intralesio...