Introduction: The SCAN gynaecological cancers systemic therapy workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for front-line systemic therapy of advanced epithelial ovarian cancer. Materials and Methods: The workgroup utilised a modifi ed ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setti...

Meningeal metastasis from cancer has become an increasingly frequent problem as the treatment of systemic disease improves. Leukemia, lymphoma and solid tumors may all metastasize to the meninges, where the blood-brain barrier may provide a sanctuary from cytotoxic concentrations of chemotherapeutic agents. Because meningeal disease may be clinically silent or may present with unusual signs and...

The reactivation of the hepatitis B virus (HBV) following systemic chemotherapy reportedly caused acute liver dysfunction as a fatal complication. HBV sometimes occurs even after cessation chemotherapy, especially in patients with hematological malignancies. A retrospective survey surface (HBs) antigen-negative cancer HBs and/or HBc antibodies was conducted by multidisciplinary team to determin...

Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. Although enucleation and external beam radiotherapy have been historically used, today the most commonly used eye-sparing approach is chemotherapy. Chemotherapy can be used in both intraocular and extraocular RB cases. Chemotherapeutic agents may be applied in different ways, including systemic, subconjunctival, intra...

In a recent issue of Annals of Oncology, Zelek et al. reported on a combination treatment of systemic [5-fluorouracil (5-FU), leucovorin (LV) and irinotecan] and hepatic arterial (pirarubicin) chemotherapy in the first-line treatment of non-resectable, metastatic colorectal cancer limited to the liver [1]. In their article, the authors report a response rate of 48% and a median survival of 20.5...

More than 90% of all liver malignancies are hepatocellular carcinomas (HCCs), for which chemotherapy and immunotherapy the ideal therapeutic choices. Hepatocellular carcinoma is descended from other diseases, such as viral hepatitis, alcoholism, metabolic syndrome. Normal cells tissues may suffer damage common forms chemotherapy. In contrast to systemic chemotherapy, localized can reduce side e...

Background: The aim of this study was to investigate the efficacy and safety of metronomic capecitabine chemotherapy in pretreated elderly patients with advanced gastric carsonoma. Patients and Methods: Eligible patients were treated with capecitabine at a fixed dose of 1000mg daily until disease progression or toxicity. Endpoints were overall response rate, safety, progression-free survival...