abstractprevious studies have shown the role of opioid receptors located in the nucleus cuneiformis (cnf) in acute pain, but not in chronic pain models. in the present study, we have determined that possible effects of these receptors at the cnf on both early and late phases of formalin test following local and systemic morphine administration. each rat was given a subcutaneous 50-μl injection ...

Mycobacterium avium causes chronic and progressive respiratory infection. A therapeutic regimen including clarithromycin, rifampin and ethambutol has been commonly employed, however, the effect of such antibacterial therapy is often unsatisfactory. Doxycycline is an antibiotic known to have immuno-modulating effects as well as antibacterial activity. In this study, we investigated the effect of...

I performed an experiment on the relationship between 14C-Bleomycin and Glutathione in 'vivo; especially on the relationship of radioactivity and antibacterial activity, and the results will be reported here. 1) When Bleomycin and Glutathione were administered simultaneously and animals were killed after 30 minutes, decrease in Bleomycin concentration in every organ was observed. The decrease r...

OBJECTIVES The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. METHODS CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injur...