CoQ10 and lycopene are isoprenoid compounds with nutraceutical and pharmaceutical benefits. In this study, the effect of concomitant lycopene biosynthesis on CoQ10 accumulation in transformed Escherichia coli DH5α was studied. A lycopene production pathway including geranylgeranyl diphosphate synthase (crtE), phytoene synthase (crtB), and phytoene desaturase (crtI) from Erwinia herbicola was co...

As products of genome mining, the stereochemical assignment macrolide antibiotics stambomycins A–D has been made on basis sequence analysis associated polyketide synthase, aside from...

1, 4, 5, 6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid (ectoine) is an excellent osmoprotectant. ectoine and hydroxyl ectoines are of great significance to the biotechnology industry, thus the detection and isolation of ectoine producing bacteria is of great importance. hence, this study involved the detection of the ectc gene (encoding ectoin synthase enzyme) using polymerase chain reacti...

Mitochondrial ATP synthase is the main enzyme of synthesis. A large number diseases, including neurodegenerative ones, are associated with disorders its assembly and functioning. The aim work to reveal patterns features regional distribution in neurons rat brain structures, a quantitative assessment content at cellular level. study was carried out on material from 5 outbred white male rats. Par...

Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological in inner membrane thought to be composed F-ATP synthase (complex V). OSCP, subunit synthase, helps protect against mPTP formation. How destabilization OSCP may contribute aging, however, unclear. We have found that loss nematode Caenorhabditis e...

Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...

Mitochondrial ATP synthase is the major producer of in respiratory cells and maintains mitochondrial membrane potential ΔΨm glycolytic cells. For these purposes, it works forward (ATP synthesis) or reverse mode hydrolysis). These two modes are not necessarily antagonistic. We provide evidence that both functional types can be found within same mitochondria. combined inhibitor studies with high-...

Relevance. The increase in the number of severe brain injuries due to stroke and traumatic injury determines need study develop effective strategies for neuroprotection. article highlights new mechanisms neuroprotective action inhalation anesthetic xenon based on data our own experimental studies. Aim study. To assess effect anesthesia with at a concentration 0.5 MAC (minimum alveolar concentra...

Riboflavin synthase is an important enzyme catalyzing the last step of riboflavin biosynthesis in microorganisms. Due to absolute dependency microbes this biosynthetic pathway coupled with its nonexistence humans, (RiS) considered as a prospective drug target. The for study was derived from Leptospira kmetyi, pathogenic bacterium locally isolated Malaysia. Leptospirosis, infectious disease caus...