نتایج جستجو برای: synovial cell
تعداد نتایج: 1696809 فیلتر نتایج به سال:
Rheumatoid arthritis is exclusively a disease of man, and lack of an experimental animal model has impeded progress in understanding the etiology and pathogenesis of this destructive process. At the level of the synovial membrane, the rheumatoid process is characterized by intermittent connective tissue cell proliferation, overproduction of underpolymerized hyaluronic acid,’ increased glycolysi...
Synovial cysts of the temporomandibular joint (TMJ) are very rare, and to date, only 12 cases of a synovial cyst in the TMJ region have been reported in the literature. In this paper, we present the clinicopathological and immunohistochemical characteristics of one such lesion affecting a 48-year-old woman, presented with a mass in the left preauricular region. We describe the usefulness of imm...
OBJECTIVE Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF) antagonists is highly effective, but their mechanisms of action are not completely clear. Since anti-TNF therapy induces a decrease in synovial cellularity, this study focused on the modulation of RA synovial apoptosis following treatment with either soluble TNF receptor (etanercept) or TNF chimeric monoclonal ant...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to induce apoptosis in a variety of cell lines. In this study, we examined the effect of NSAIDs on the growth and apoptosis of synovial cells from patients with rheumatoid arthritis and analyzed the activation of peroxisome proliferator-activated receptor (PPAR ) as a possible mechanism of action of NSAIDs. Cell proliferation and ...
Nitric oxide is one of many proinflammatory mediators that are involved in temporomandibular joint (TMJ) inflammatory disorder and is synthesized by inducible nitric oxide synthase (iNOS). iNOS is transcriptionally regulated by nuclear factor-κB (NF-κB) in cases of inflammation, proliferation, and apoptosis. It has also been reported that nitric oxide is positively regulated by carrageenan and ...
PURPOSE Adoptive immunotherapy using tumor-infiltrating lymphocytes represents an effective cancer treatment for patients with metastatic melanoma. The NY-ESO-1 cancer/testis antigen, which is expressed in 80% of patients with synovial cell sarcoma and approximately 25% of patients with melanoma and common epithelial tumors, represents an attractive target for immune-based therapies. The curren...
BACKGROUND Recent studies suggest that the vasodilatory neuropeptide calcitonin gene-related peptide (CGRP) is localized in the synovial tissue and may be involved in the pathology of hip and knee osteoarthritis (OA). However, the regulation and relationship between pain and CGRP expression levels in the synovial tissue of human OA patients are not fully understood. METHODS Synovial tissues w...
BACKGROUND Pathological bone resorption (marginal erosions and juxta-articular osteoporosis) by osteoclasts commonly occurs in rheumatoid arthritis (RA). OBJECTIVES To define the nature of the mononuclear precursor cells from which osteoclasts are formed in inflamed synovial tissues and to determine the cellular and humoral factors which influence osteoclast differentiation. METHOD Macropha...
To the Editor: In their Rational Clinical Examination article, Dr Margaretten and colleagues concluded that the synovial fluid white blood cell count and the corresponding percentage of polymorphonuclear cells are the most useful markers in identifying septic arthritis while waiting for the Gram stain and culture test results. Synovial fluid glucose, protein, and lactate dehydrogenase were not ...
Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid. Design: Clinical study. Animals: Eleven standard breed horses (seven high performances and four controls). Procedures: Blood serum and fetlock...
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