During the last few decades, consumption of low-calorie sweeteners, as a substitute for caloric has sharply increased. Although research shows that versus sweeteners can have differential effects on brain, it is unknown which neuronal populations are responsible detecting difference between two types sweeteners. Using in vivo two-photon calcium imaging, we investigated how drinking sucrose or s...

This study was carried out to disclose effects generated by the uncoupling of the sensory and energetic components of sweet solutions. A comparison was made between equi-sweet preloads of three intense sweeteners (saccharin, aspartame and acesulfame-K), a bulk sweetener (glucose) and a nonsweet water control. Measures were made of subjective ratings of motivation to eat, food preferences and en...

Baur FJ (1973) J. Am. Oil. Chem. Soc. 50: 85. Combes RD and Haveland-Smith RB (1982) Mutat. Res. 98: 101. Grendy TH (1991) Intense Sweeteners for Food Industry: An Overview. Trends in Food Sci. Tech., 2: 1. Klein H and Leubolt R (1993) J. Chromatogr. 640: 259. Kurihara Y and Nirasawa S (1994) Sweet, antisweet and sweetness-inducing substances. Trends in Food Sci. Tech. 5: 37. Macrae R (1982) HP...

Genetically diabetic db/db mice show greater neural and behavioral responses to sugars than lean control mice. The present study examined chorda tympani responses of db/db mice to nonsugar sweeteners and their inhibition by a sweet response inhibitor, gurmarin. The results showed that responses to sucrose, saccharin, glycine,l-alanine, andd-tryptophan, but not tod-phenylalanine, were ∼1.5 times...

The Tas1r3 gene encodes the T1R3 receptor protein, which is involved in sweet taste transduction. To characterize ligand specificity of the T1R3 receptor and the genetic architecture of sweet taste responsiveness, we analyzed taste responses of 129.B6-Tas1r3 congenic mice to a variety of chemically diverse sweeteners and glucose polymers with three different measures: consumption in 48-h two-bo...

BACKGROUND The role of sweeteners on cancer risk has been widely debated over the last few decades. To provide additional information on saccharin and other artificial or low-calorie sweeteners (mainly aspartame), we updated the analysis of an integrated network of case-control studies conducted in Italy between 1991 and 2004 including data on cancers of the stomach, pancreas, and endometrium. ...

Low-calorie sweeteners are chemicals that offer the sweetness of sugar without the calories. Consumers are increasingly concerned about the quality and safety of many products present in the diet, in particular, the use of low-calorie sweeteners, flavorings, colorings, preservatives, and dietary supplements. In the present study, we evaluated the mutagenicity of the three low-calorie sweeteners...

AIM to evaluate the presence of preservatives, dyes, sweeteners and flavouring substances in 73 pharmaceutical preparations of 35 medicines for oral administration, according to drug labeling information about the excipients. METHODS 35 medications were selected, both over-the-counter and prescription drugs, marketed in Brazil. The sample included: analgesic/antipyretic, antimicrobial, mucore...

Over 60% of soft-drinks sold in the United States contain caffeine, a mildly addictive psycho-active chemical, as a flavor additive. Using sweeteners as controls, we assessed whether caffeine has flavor activity in a cola soft-drink. A forced-choice triangle discrimination methodology was used to determine detection thresholds of caffeine in sweeteners and a cola beverage. The subjects (n=30, 2...

Cette communication brève vise à présenter un condensé des 9 conférences données en digital entre le 2 et 23 février 2021 lors du workshop de la SFN partenariat avec l’International Sweeteners Association autour « Édulcorants réduction sucre ». This short aims to present a summary of the lectures given digitally between February and 23, during in partnership with International on “Sweeteners su...