To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for multiple (~50) individual, identified glands in each subject. Sweating was stimulated by intradermally injected agonists and quantified by optically measuring spherical sweat bubbles in an oil-layer that contained dispersed, water soluble dye pa...

Sweat retention due to obstruction of the sweat duct in the presence of functioning glandular acini plays a pr mary role in miliaria crystallina (1, 2) miliaria rubra (3, 4) tropical anidrosis (4, 5, 6) Fox-Fordyce disease (7), and hidrocystoma (8, 9). In addition, sweat duct obstruction may occur secondarily in ichthyosis, atopic dermatitis and in seborrheic dermatitis (10). It might be expect...

In this paper, the dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands is performed by the time-sequential piled-up en-face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en-face OCT images. St...

BACKGROUND Several subtypes of sweat gland carcinoma have been found to demonstrate a propensity to metastasize systemically and to regional lymph nodes. The predictive value and benefit of sentinel lymph node (SLN) biopsy have been established in numerous other malignancies, but to the authors' knowledge there is little literature published to date regarding the use of SLN biopsy in patients w...

UNLABELLED Sweat glands perform a vital thermoregulatory function in mammals. Like other skin appendages, they originate from epidermal progenitors. However, they have low regenerative potential in response to injury, and whether adult epidermal progenitors could be specified to differentiate to a sweat gland cell lineage remains largely unexplored. We used bioprinting technology to create a fu...

The purpose of this study was to determine the effect of active heat acclimation on the sweat osmolality and sweat sodium ion concentration vs. sweat rate relationship in humans. Eight healthy male volunteers completed 10 days of exercise in the heat. The mean exercising heart rate and core temperature were significantly decreased (P < 0.05) by 18 beats/min and 0.6 degrees C, respectively, foll...

This paper attempts to further clarify the characteristics of Mecholyl- or epinephrine-stimulated glucose metabolism in the isolated monkey eccrine sweat gland with special emphasis on its relationship to increased sodium transport. The Mecholyl- or epinephrine-stimulated glucose metabolism (as estimated by either lactate or (14)CO(2) production or both) is seen only in the secretory coil and n...

Hidradenocarcinoma (HAC) is an exceedingly rare and aggressive malignant tumor of the adnexal eccrine apocrine sweat gland. Due to its low incidence rate, nonspecific clinical presentation, similar histopathological features benign hidradenoma (HA), HAC often misdiagnosed as counterpart.

This paper addresses the ways in which heat loss effector functions change with maturation and aging, using data obtained in our laboratory. Prepubertal children have an underdeveloped sweat function compared with young adults; this is compensated by a greater surface area-to-mass ratio and relatively greater heat loss from cutaneous vasodilation on the head and trunk when the air temperature i...