In the United States acetaminophen (paracetamol) is the most commonly used nonprescription analgesic. In addition to its nonprescription use, acetaminophen is also a common ingredient of prescription opioid combination products. This case report describes an acetaminophen-related fatality that occurred as a consequence of an unintentional overdose of a prescribed hydrocodone/acetaminophen produ...

However, we disagree with Dr Lee that the toxicity should be attributed solely to rectal paracetamol. Firstly, the pharmacokinetics of rectal paracetamol have been extensively studied, and it has been suggested that even a rectal regimen of 25 mg/kg every 6 hours for a mean of 2 to 3 days did not result in supratherapeutic concentration. Secondly, because oral and rectal paracetamol are metabol...

The maximum daily dose of vitamin D currently recommended is 2000 IU. Ergocalciferol (D2) 50,000 IU orally weekly for 8-12 weeks is often used to treat vitamin D deficient patients (25(OH) vitamin D <20 ng/mL). The lack of vitamin D toxicity after massive doses of ergocalciferol has yet to be reported in the literature. We report a case of a 56-year-old woman who received supratherapeutic doses...

Ibuprofen is widely used in the community to manage pain, inflammation and fever. In cases of prolonged and supratherapeutic ingestion of ibuprofen, renal tubular acidosis (RTA) with profound hypokalemia may occur. Although hypokalemia is known to cause rhabdomyolysis, rhabdomyolysis occurring in the setting of ibuprofen-induced RTA is rare. We present an unusual case of a 34-year-old male who ...