This study tested the hypothesis that vitamin E (Vit E) and omega-3 fatty acids will additively attenuate the production of proinflammatory cytokines and PGE2 in immune system–stimulated growing–finishing pigs. A total of 80 mixed sex pigs weighing 50.7 ± 0.76 kg (mean ± SE) were blocked and stratified based on sex and BW to a 2 × 2 factorial design with the respective factors being 1) without ...

background: vitamin d, especially its most active metabolite 1,25-dihydroxyvitamin d₃(vit d) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. the objective of this study was to assess the histopathological changes of effectiveness of vit d as a protective agent against radiation induced lung injury. materials and methods: eighteen wi...

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated myocardial inflammation and subsequent cardiac contractile dysfunction. Sepsis was produced in adult male Sprague-Dawley rats via intratracheal injection of S. pneumonia (4 × 10(6) colony formation units per rat). A single...

Ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) have antioxidant properties that could improve redox-sensitive vascular changes associated with hypertension. We determined whether vitamins C and E influence vascular function and structure in hypertension by modulating activity of NADPH oxidase and superoxide dismutase (SOD). Adult stroke-prone spontaneously hypertensive rats (SHRSP) ...

Objective(s): Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH’s neurodegenerative changes.Materials and Methods: Two groups of 6 animals received METH (10...

Weanling crossbred pigs (Sus scrofa; 72 barrows and 72 gilts; BW = 7.4 ± 1.1 kg) were used to evaluate dietary supplemental trace mineral (Cu, Fe, Mn, and Zn) source (inorganic vs. organic) and deletion (0, 2, 4, and 6 wk preharvest) on growth performance, carcass characteristics, and pork quality. Pigs were blocked by BW, ancestry, and sex, and randomly allotted to 24 pens, and fed a diet cont...

Introduction:Stomach cancer is the leading cause of cancer related death worldwide, hence known as CAPTAIN OF MENS DEATH.Vitamin -c is an antioxidant and inhibitor of carcinogen N-nitroso compound production in the stomach.Numerous case control studies show that higher dietary vitamin -c consumption is associated with decreased risk of gastric cancer but prospective studies are limited,particul...

Klotho protein is recognized as having a renoprotective effect and is used as a biomarker for kidney injury. We investigated the level of Klotho protein in hyperoxaluria-induced kidney injury and the effects of vitamin E (Vit E) and vitamin C (Vit C) supplementation. Hyperoxaluria was induced by feeding 2% (w/v) Hydroxy-L-proline (HLP) in the drinking water for 21 days. Rats were divided into 5...