Solute diffusion in hydrogels is important in many biotechnology fields. Solute behavior in hydrogels has been explained in terms of reduction in hydrogel free volume, enhanced hydrodynamic drag on the solute, increased path length due to obstruction, and a combination of hydrodynamic drag and obstruction effects. In this article the various mathematical models derived to explain and predict so...

Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can...

Since 1960 when the history of modern hydrogels began significant progress has been made in the field of controlled drug delivery. In particular, recent advances in the so-called smart hydrogels have made it possible to design highly sophisticated formulations, e.g., self-regulated drug delivery systems. Despite intensive efforts, clinical applications of smart hydrogels have been limited. Smar...

The large availability of cellulose in nature and the low cost of cellulose derivatives make the cellulosebased hydrogels particularly attractive. New hydrogels were obtained by chemical cross-linking of different cellulose allomorphs (cellulose I, cellulose II and cellulose III) and xanthan with epichlorohydrin. The preparation conditions of the transparent cellulose hydrogels were established...

PVP-CMC and PVP-CMC-BA are designated as medicated hydrogels which are elastic in nature like other gels and solids. This present work was focused on the effect of strain on viscoelastic behavior of these medicated hydrogels. Dynamic frequency sweep test at 10% strain and dynamic strain sweep tests at different angular frequencies were performed on these hydrogels. Freshly prepared hydrogels an...

Poly(vinyl alcohol)-heparin hydrogels with varying water content were synthesized for use as sensor catheter membranes. Films were cast from aqueous mixtures of poly(vinyl alcohol) (PVA), a photosensitive cross-linker p-diazonium diphenyl amine polymer (PA), glutaraldehyde (GA) and heparin. After drying, the films were cross-linked by successive UV irradiation and heat treatment. To get an indi...

In this work, antioxidant hydrogels were prepared by the construction of an interpenetrating chitosan network and functionalization with gallic acid. The poly(2-hydroxyethyl methacrylate) p(HEMA)-based hydrogels were first synthesized and subsequently surface-modified with an interpenetrating polymer network (IPN) structure prepared with methacrylamide chitosan via free radical polymerization. ...

Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(L-glutamic acid)/chitosan (PLGA/CS) hydrogels were fabricated by selfcrosslinking aldehyde-modified PLGA (PLGA–CHO) and lactic acid-modified chitosan (CS–LA). The oxidation degree of PLGA–CHO and degree of substitution (DS) of CS–LA could be adjusted by the amount o...

The development of hydrogels for cartilage replacement and soft robotics has highlighted a challenge: load-bearing hydrogels need to be both stiff and tough. Several approaches have been reported to improve the toughness of hydrogels, but simultaneously achieving high stiffness and toughness remains difficult. Here we report that alginate-polyacrylamide hydrogels can simultaneously achieve high...