نتایج جستجو برای: superoxide dismutasecatalase

تعداد نتایج: 33639  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1980
W F Petrone D K English K Wong J M McCord

The intravenous administration of superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) to animals with induced inflammation suppresses the inflammatory response and inhibits leukocyte infiltration into the challenged site, suggesting that neutrophil-generated superoxide reacts with an extracellular precursor to generate a substance chemotactic for neutrophils. Plasma exposed...

Journal: :The Journal of biological chemistry 1988
M A Hass D Massaro

Heat shock proteins are induced at normal temperatures by oxidants and during reoxygenation following hypoxia. We now report cyanide-resistant O2 consumption increased 30-50% in rat lungs exposed to heat shock or reoxygenation following hypoxia. The synthesis of Cu,Zn superoxide dismutase, but not Mn superoxide dismutase, was increased in rat lung slices by in vivo hyperthermia (39 degrees C), ...

Journal: :Molecular carcinogenesis 1999
J Q Yang S Li F E Domann G R Buettner L W Oberley

The oncogenic ras protein controls signal-transduction pathways that are critical for cell proliferation and tumorigenesis. Here, we demonstrate that v-Ha-ras-transduced human keratinocyte HaCaT cells produced significantly larger amounts of superoxide than did control cell lines. The superoxide generation was mediated by the transduced ras protein, because superoxide generation was modified by...

Journal: :Cell 2008
Wang Wang Huaqiang Fang Linda Groom Aiwu Cheng Wanrui Zhang Jie Liu Xianhua Wang Kaitao Li Peidong Han Ming Zheng Jinhu Yin Weidong Wang Mark P. Mattson Joseph P.Y. Kao Edward G. Lakatta Shey-Shing Sheu Kunfu Ouyang Ju Chen Robert T. Dirksen Heping Cheng

In quiescent cells, mitochondria are the primary source of reactive oxygen species (ROS), which are generated by leakiness of the electron transport chain (ETC). High levels of ROS can trigger cell death, whereas lower levels drive diverse and important cellular functions. We show here by employing a newly developed mitochondrial matrix-targeted superoxide indicator, that individual mitochondri...

Journal: :The Journal of biological chemistry 1987
M D Scott S R Meshnick J W Eaton

Superoxide dismutase is considered important in protection of aerobes against oxidant damage, and increased tolerance to oxidant stress is associated with induction of this enzyme. However, the importance of superoxide dismutase in this tolerance is not clear because conditions which promote the synthesis of superoxide dismutase likewise affect other antioxidant enzymes and substances. To clari...

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