Infections remain the most common immediate causes of morbidity in immune compromised hosts. The abated host defences are responsible for an increased susceptibility to various uncommon and opportunistic pathogens, and to a lowered host inflammatory response. Skin lesions develop in up to a third of infections in these patients, and they possibly represent the initial step of a systemic illness...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 2095 are not typically amenable to topical therapy, they will not be discussed in this article. It is important to note that nondermatophytes and yeasts may infect the sites mentioned above. For example, tinea unguium is only a subset of the onychomycoses, which include other types of fungal infections of the nails. Similarly, tinea corporis refers onl...

results the results of energy-dispersive x-ray demonstrated that the purified nps consisted of only se. in addition, transmission electron micrographs showed that 120- to 140-nm spherical se nps were the most common. an antifungal assay was performed with a standard clinical and laboratory standards institute broth microdilution method. minimum inhibitory concentration (mic) measurements of the...

Fungal infections are worldwide distributed and are associated with high morbidity rates, and in immunocompromised populations, are usually life-threatening conditions. The host-fungus interaction is critical for tissue adhesion, colonization and damage. Here, we provide a series of comprehensive review and original papers dealing with both aspects of this interaction: the role of virulence fac...

The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal inf...

Most fungal infections of the cornea are secondary infections, caused by opportunis­ tic fungi that have invaded a diseased cornea or one that has been treated with corticosteroids or broad-spectrum antibiotics. Two ex­ ceptions are corneal infections due to Can­ dida albicans or Aspergillus species; these may infect an apparently normal cornea af­ ter minimal trauma. Superficial mycotic infect...

deep-seated fungal infection present with non specific symptoms and involove a large number of different organisms. dna-based technology offers for eariler detection of fungal pathogens and then earlier initiation of antifungal therapy. in this study universal primers common to almost all fungi were used to amplification of internal transcribe spacer 1 and 2 region. subsequent restriction enzym...

despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. a large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. a variety of techniques...

Ivan Bristow is Lecturer, School of Health Sciences, University of Southampton; Manfred Mak is Podiatrist, Singapore General Hospital, Singapore When discussing tissue viability in the lower limb, much attention is focused on the role of bacterial infection. However, fungal skin infection is a more frequent and more recurrent pathogen which often goes undetected by the practitioner and patient ...

Candida albicans is an opportunistic human fungal pathogen which is involved in infections ranging from superficial, mucosal to systemic candidiasis. It is the fourth most leading cause of death in nosocomial infections. Candidal infections are increasing at an alarming rate due to poor clinical management in hospital settings, more use of antibiotics, increased drug resistance, immunosuppressi...