We synthesized a new chalcone (4,2'-dihydroxy-3methoxy-5-bromine chalcone; C) and structurally identified it via infrared spectrometry (IR), (1)H-NMR, mass spectrometry (MS) and element analysis (EA). C was confirmed to be highly potent in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Tests of anti-free radical activity in response to oxidative stress in mice r...

Radical scavenging activity of ethanolic extract of Trianthema triquetra root was investigated against CCl4 in rats. The rats were treated with T. triquetra (100 mg, 200 mg/kg b.w.) for a period of 7 days. Antihepatotoxic effect was studied by assaying the activities of thiobarbituric acid (TBARS), reduced glutathione (GSH), glutathione peroxidase (GPx),catalase (CAT), super oxide dismutase (SO...

Pigment epithelium-derived factor (PEDF) has many biological activities. But it's not known whether PEDF and its functional peptides could protect against hypoxia-induced cell death and the mechanisms are still unclear. We used cultured H9c2 cells and primary cardiomyocytes to show that apoptosis and necroptosis were significantly increased after hypoxia. Both PEDF and its fuctional peptides 44...

Oral pre-treatment with ethanolic extract of the roots of C. carandas (ERCC; 100, 200 and 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 and paracetamol induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and prote...

OBJECTIVE To study the focal cerebral ischemia/reperfusion (I/R) injury induced by a middle cerebral artery occlusion (MCAO), and the effects of Yulangsan (YLS) polysaccharide on this injury. METHODS This study took place in the Pharmacology Research Laboratory at Guangxi Medical University, China, between March and May 2007. Two hundred and forty rats were randomly divided into I/R group, sh...

in this paper the role of super paramagnetic iron oxide nanoparticles (spi) on platinum nanoclusters on activated carbon (pt/c) for electrocatalytic oxygen reduction reaction was considered. four composites of pt/c and super paramagnetic iron oxide nanoparticles were prepared with the same total composites weight and different loading of pt/c (1.2, 0.6, 0.4 and 0.3 mg ). the composite attached ...

This study evaluated the effects of live yeast (LY, Saccharomyces cerevisiae) on growth performance, nutrient digestibility, immune function, antioxidant status and intestinal morphology broilers. A total 224, 1 day-old broilers were assigned 4 treatments (7 replications, 8 chicks each) fed a basal diet control group (CTR); antibiotic (CTC) diets with chlortetracycline at 75 mg/kg; LY-1 LY-2 gr...

The aim of the present study was to look into the possible protective effects of glycyrrhizic acid (GA) against isoproterenol-induced acute myocardial infarction in Sprague-Dawley rats. The effect of three doses of glycyrrhizic acid in response to isoproterenol (ISO)-induced changes in 8-isoprostane, lipid hydroperoxides, super oxide dismutase and total glutathione were evaluated. Male Sprague-...