17alpha-Ethinylestradiol (EE2), a component of oral contraceptives, is known to undergo considerable first-pass 3-O-sulfation in the intestine and liver. Once formed, the 3-O-sulfate conjugate (EE2-Sul) is detected in circulation at appreciable levels (versus parent EE2) and is present in bile. Therefore, hepatic uptake of EE2-Sul was assessed with suspensions of cryopreserved human primary hep...

1 Otorhinolaryngologist (Fellow of the Larynx, Clinic Hospital, Porto Alegre). 2 Otorhinolaryngologist (Hired medical doctor of the Clinic Hospital, Porto Alegre. Master’s degree in pediatrics, Rio Grande do Sul Federal University). 3 Otorhinolaryngologist (Master’s degree student, Rio Grande do Sul Federal University). 4 Otorhinolaryngologist (Master’s degree in pediatrics, Rio Grande do Sul F...

Shocked that chemical offshoots of his company's products were winding up in polar bears and seals, the CEO of 3M put an end to the existing version of Scotchgard® in 2000. Business observers were struck by how quickly this multinational corporation removed a flagship commodity worth hundreds of millions of dollars from the market. Now some scientific observers are becoming impressed by how qui...

Amoxicillin-sulbactam (AMX-SUL) is an aminopenicillin/ss-lactamase inhibitor combination currently available in 29 countries and may be a suitable option for treating infections caused by Acinetobacter spp. Thus, we sought to search the optimal dosing strategy for this formulation through an ex vivo pharmacodynamic human model against Acinetobacter baumanniii. Four volunteers were randomized to...

1. Graduate Program in Food Science and Technology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 2. Biotechnology Center, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 3. Department of Microbiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 4. Department of Microbiology, Federal Foundation of Medical Sciences of Porto Alegre, R...

Several cytogenetic markers show chromosomal diversity in the fish such as "armoured catfish". Although studies have characterized many species in the major genera representing these Siluridae, particularly in the genus Hypostomus Lacépède, 1803, trends in chromosome evolution of this group remain unclear. The Paraíba do Sul river basin contains the armoured catfish Hypostomus affinis Steindach...

Taís Silveira Assmann1,2, Natália Emerim Lemos1,2, Letícia de Almeida Brondani1,2, Rodrigo Carlessi1,2, Carmen Maldonado-Bernal3,4, Miguel Cruz3,4, Luis Henrique Canani1,2 and Daisy Crispim1,2* 1Endocrine Division, Hospital de Clínicas de Porto Alegre. Porto Alegre, Rio Grande do Sul, Brazil 2Postgraduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul. Por...

(1) Speech-Language Pathologist; Associate Professor of the Undergraduate Program in Speech Language Pathology and Graduate Program in Human Communication Disorders at Universidade Federal de Santa Maria – UFSM, Santa Maria, Rio Grande do Sul, Brazil; Doctorate in Applied Linguistic from the Pontifícia Universidade Católica do RS – PUCRS. CNPq PQ Fellowship. (2) Physiotherapist, Professor of Ph...

Toxin production and the presence of the toxA gene was assayed in 24 Pasteurella multocida strains isolated from pigs with pneumonia and pleuritis in the State of Rio Grande do Sul, Brazil. Toxigenicity was assessed through a mouse lethality test and a PCR amplification assay was used to obtain a 300 bp product from the toxA gene. In order to demonstrate that the amplified product corresponded ...

MENINGOENCEFALOPATIA PRECOCE ASSOCIADA COM O USO INTRAOPERATÓRIO DE OKT3 EM RETRANSPLANTE RENAL Medical Student, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre RS, Brazil; MD, Division of Nephrology, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria RS, Brazil; MD, PhD, Adjunct Professor, Department of ...